Ashot Kozak, Ph.D.

Department:
NeuroScience Cell Bio Physio-COSM
Title:
Associate Professor
Address:
Biological Sciences Bldg II 148A, 3640 Colonel Glenn Hwy, Dayton, OH 45435
Phone:
937-775-4514
Education History: 

Ph.D.: Mount Sinai School of Medicine
New York City, 1998
Postdoctoral: University of California at Irvine

Academics

Human Physiology (BMS 8620): Immunity, Blood, Molecular Endocrinology
Neuroscience and Physiology (BMS 8750): Pain and Ion Channels, Control of Intracellular Calcium
Endocrine (SMD 561): Physiology of Parathyroid Glands
Ion Channels (BMS 8530): TRP channels

Research statement: 

Cation channels expressed in leukocytes; Transient Receptor Potential (TRP) channels; ion channels involved in nociception.

Funding: National Institute of Allergy and Infectious Diseases (NIAID)

Professional

Publications: 

Kaitsuka, T.,  Katagiri, C., Beesetty, P., Nakamura, K., Hourani, S., Tomizawa, K.,  Kozak, J.A., Matsushita, M. (2014) Inactivation of TRPM7 kinase activity does not impair its channel function in mice. Scientific Reports 4: 5718.

Chokshi R, et al. (2012) 2-Aminoethyl diphenyl borinate (2-APB) inhibits TRPM7 channels through an intracellular acidification mechanism. Channels (Austin) 6 (5): 362-369.

Chokshi, R. H., Matsushita, M., Kozak, J.A. (2012) Sensitivity of TRPM7 channels to Mg2+ characterized in cell-free patches of Jurkat T lymphocytes. Am. J. Physiol. Cell Physiol. 302: C1642-1651.

Chokshi, R. H., Matsushita, M., Kozak, J.A. (2012) Detailed examination of Mg2+ and pH sensitivity of human TRPM7 channels. Am. J. Physiol. Cell Physiol. 302(7): C1004-C1011.

Lioudyno, M.I., Broccio, M., Sokolov, Y., Rasool, S., Wu, J., Alkire, M.T., Liu, V., Kozak, J.A.,Dennison, P.R., Glabe, C.G., Lösche, M., Hall, J.E. (2012) Effect of synthetic Aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance. PLoS One 7(4): e35090.

Zhang S.L.*Kozak J.A.*, Jiang W., Yu Y., Penna, A., Chi V., Cahalan, M.D. (2008) Store-dependent and -independent modes regulating Ca2+ Release-Activated Ca2+ channel activity of human Orai1 and Orai3. J. Biol. Chem. 283:17662-17671. *equal contributors

Lioudyno M.I., Kozak, J.A., Penna A., Safrina O., Zhang S.L., Roos J., Stauderman K.A., Cahalan M.D. (2008) Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation. Proc. Natl. Acad. Sci. USA 105(6):2011.

Jovanovska, A., Karczewski, J., Cook, S. and Kozak J.A. (2007) Regulation of proton-activated ASIC1 channels by extracellular organic cations. Society for Neurosci. Annual Meeting Abstract.

Sokolov Y., Kozak J.A., Kayed, R., Chanturiya A., Glabe, C., Hall, J.E. (2006) Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure. J. General Physiol. 128:637.

Zhang, S.L., Yu, Y., Roos, J., Kozak, J.A., Deerinck, T.J., Ellisman, M.H., Stauderman, K.A., Cahalan, M.D.(2005) STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature 437:902.

Kozak, J.A., Matsushita, M., Nairn, A.C., Cahalan, M.D. (2005) Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition and rundown of TRPM7/MIC channels. J. General Physiol.126(5):499.

Matsushita M., Kozak J.A., Shimizu Y., McLachlin D.T., Yamaguchi H., Wei F.Y., Tomizawa K., Matsui H., Chait B.T., Cahalan M.D., Nairn A.C. (2005) Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1. J. Biol. Chem. 280(21):20793.

Kozak J.A., Cahalan M.D. (2003) MIC channels are inhibited by internal divalent cations but not ATP.Biophysical Journal 84(2 Pt 1):922.

Kozak J.A. et al. (2002) Distinct Properties of CRAC and MIC Channels in RBL Cells. J. General Physiol.120(2):221.

Perez C.A., Huang L., Rong M., Kozak J.A., Preuss A.K., Zhang H., Max M., Margolskee R.F. (2002) A transient receptor potential channel expressed in taste receptor cells. Nature Neuroscience 5(11):1169.

Kozak J.A.Misler, S., Logothetis, D.E. (1998) Characterization of a Ca2+-activated K+ current in insulin-secreting murine βTC-3 cells. Journal of Physiology 509 (Pt. 2):355.

Professional Affiliations/Memberships: 

Service

Mediation Committee, WSU College of Science and Mathematics

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