Lynn K Hartzler, Ph.D.
My research interests include examining how animals adapt to environmental (temperature changes) and metabolic (exercise, feeding, etc.) perturbations to their acid-base status. Alterations in breathing are the primary, acute response to a metabolic acidosis or alkalosis. Current projects in my lab involve experiments designed to understand how central (brainstem) chemoreceptors sense changes in blood gases and pH. We use the combined techniques of fluorescence imaging microscopy and whole-cell electrophysiology to measure neuronal responses to changes in CO2, O2, and pH in brainstem neurons of poikilothermic vertebrates. I am interested in understanding how these chemoreceptors are altered by changes in the animal's environment.
Santin, J.M. and Hartzler, L.K. (2015) Activation state of the hyperpolarization-activated current modulates temperature-sensitivity of firing in locus coeruleus neurons from bullfrogs. Am. J. Physiol. Regul. Integr. Comp. Physiol. 308(12): R1045-61. DOI:10.1152/ajpregu.00036.2015
Patrone, L.G.A., Bícego, K.C., Hartzler, L.K., Putnam, R.W., and Gargaglioni, L.H. (2014) Cardiorespiratory effects of gap junction blockade in the locus coeruleus in unanesthetized adult rats. Respiratory Physiology and Neurobiology. 190:86-95. DOI: 10.1016/J.RESP.2013.09.001
Santin, J.M., Watters, K.C., Putnam, R.W., and Hartzler, L.K. (2013) Temperature influences neuronal activity and CO2/pH sensitivity of locus coeruleus neurons in the bullfrog, Lithobates catesbeianus. American Journal of Physiology, Regulatory, Integrative, and Comparative Physiology 305(12): R1451-1464 DOI: 10.1152/ajpregu.00348.2013
Santin, J.M., and Hartzler, L.K. (2013) Respiratory signaling of locus coeruleus neurons during hypercapnic acidosis in the bullfrog, Lithobates catesbeianus. Respiratory Physiology and Neurobiology. 185(3): 553-561. doi:10.1016/j.resp.2012.11.002
Reinert, B.L., Pohlman, R.L., and Hartzler, L.K. (2012). Correlation of Air Displacement Plethysmography with Alternative Body Fat Measurement Techniques in Men and Women. International Journal of Exercise Science 5(4): 367-378.
Sheehan, K.M. and Hartzler, L.K. (2011). Effects of XS® Energy Drink on Aerobic Exercise Capacity of Athletes. International Journal of Exercise Science 4(2): 152-163.
Gargaglioni, L.H., Hartzler, L.K., Putnam, R.W. (2010). The locus coeruleus and central chemosensitivity. Respiratory Physiology and Neurobiology 173(3): 264-273.
Kersh, A.E., L.K. Hartzler, K. Havlin, B. Hubbell, V. Nanagas, A. Kalra, J. Chua, R. Whitesell, N.A. Ritucci, J.B. Dean and R.W. Putnam. (2009). pH regulating transporters in neurons from various chemosensitive brainstem regions in neonatal rats. Am. J. Physiol. Regul. Integr. Comp. Phsyiol. 297(5): R1409-20.
Hartzler, L.K., Putnam, R.W. (2009). Central Chemosensitivity in Mammals. In Cardio-Respiratory Control in Vertebrates: Comparative and Evolutionary Aspects. Eds. M.L. Glass and S.C. Wood. Springer-Verlag, Berlin, Germany.