The overall objective of my research is to understand the interactions between virus and the host defense system occurring between the first 12 to 24 hours of infection (innate immunity) which leads to susceptibility or resistance to disease (acquisition of adaptive immunity). Previously, the research projects under this objective dealt with: a gender-based difference to the pathogenesis of a picornavirus [the D variant of emcephalomyocarditis virus  {EMCV-D] and a DNA vaccine for herpes simplex virus, type 1 (HSV-1). My ongoing research involves HSV-1, cytokine signaling pathways, SOCS1/SOCS3 in inflammatory/anti-inflammatory cytokine pathways and cytoskeletal changes in macrophages polarized to the M1 and M2 phenotypes.

Published Articles

Bigley NJ. 2016. M1 and M2 Myeloid Cells in Inflammation. J Cell Signal 1:2

Bigley NJ. 2015. Putative Roles of SOCS1: SOCS 3 Ratios in Development and Resolution of a Herpesvirus Lesion. J Cell Signal 1:101. doi:10.4172/jcs.1000101

Bigley NJ. 2014. Complexity of Interferon-g Interactions with HSV-1. Frontiers in Immunology/Immunotherapies and Vaccines. Feb 2014/vol 5/article 15.

Reichard AC, Cheemarla NR, Bigley NJ. SOCS1/3 Expression Levels in HSV-1-Infected, Cytokine-Polarized and -Unpolarized Macrophages. J Interferon Cytokine Res. 2014 Jun 23. [Epub ahead of print]

Rogers JV, Hull BE, Fink PS, Chiou HC, Bigley NJ. 2000. Murine response to DNA encoding herpes simplex virus type-1 glycoprotein D targeted to the liver. Vaccine 18:1522-1530.

Cruz PE, Khalil PL, Dryden TD, Chiou HC, Fink PS, Berberich SJ, Bigley NJ. 1999. A novel immunization method to induce cytotoxic T-lymphocyte responses (CTL) against plasmid-encoded herpes simplex virus type-1 glycoprotein D. Vaccine 17:1091-1099.

Mason KM, Bigley NK, Fink PS. 1998. Development of a novel in vitro co-culture system for studying host response to native bacterial antigens. J Immunol Meth 211:147-158.

Curiel RE, Mason KM, Dryden TD, Maurer MJ, Bigley NJ. 1998. Cytokines produced early in picornavirus infection reflect resistance or susceptibility to disease. J Interferon Cytokine Res 18:587-596.

Mason KM, Dryden TD, Bigley NJ, Fink PS. 1998. Staphylococcal enterotoxin B primes cytokine secretion and lytic activity in response to native bacterial antigens. Infect Immun 66:5082-5088.

Curiel RE, Miller MH, Ishikawa R, Thomas DC, Bigley NJ. 1993. Does the gender difference in interferon production seen in picornavirus-infected spleen cell cultures from ICR Swiss mice have any in vivo significance? J Interferon Res 13:387-395.

Published Abstracts and Presentations

Bigley NJ. 2014. Differential expression of SOCS1/SOCS3 ratios in virus-infected macrophage cell lines.  J Clin & Cell Immunol Sept 2014, vol 5:53. This abstract was from the invited presentation at the 3rd International Conference and Exhibition on Clincal & Cellular Immunology entitled Immunology Summit 2014, Baltimore.

Asma. Abbas and Nancy Bigley. 2014. Latent HSV-1 infection can be established in keratinocyte cells following treatment with mitotic inhibitors. 4th International Conference on Biological and Medical Sciences (ICBMS'14) Oct. 9-10, 2014 Antalya (Turkey).