James Edwin Olson, PhD

Emergency Medicine
Director of Research Laboratory and Professor of Emergency Medicine Professor, Neuroscience, Cell Biology, & Physiology
Cox Institute, 3525 Southern Blvd, Kettering, OH 45429-1221
Laboratory Photo - July 2015 (L-R) John Trentini (Emergency Medicine Resident), Jim Olson (Research Laboratory Director), Brian Tucker (Emergency Medicine Resident), Nancy Andrews (Research Secretary), Madelyn Jones (Undergraduate Student), April Daubenspeck (Ph.D. Student), Guangze Li (Research Faculty), and Nicholas Seitz (Undergraduate Student)

Research Interests

Mechanisms of brain edema, Brain damage resulting from edema, Cellular volume regulation, Membrane channel activation during cell swelling, Blood-brain barrier water transport.

Active Grants

Wright State University Boonshoft School of Medicine Translational Grant Program.  9/1/2016 – 8/31/2018  Title: Diagnostic Biomarkers of Ischemic Stroke Identified in Patient Blood


(L-R) Drs. Megan Dines, James Olson and Jill Aston at the 2008 ACEP Research Forum.

Selected Bibliography (2007 – 2015) from 79 Articles and Chapters

Marco, Catherine A.; Edgell, Ashlee; Eggers, Catherine; Fagan, Christopher; and Olson, James E.  Altered mental status among geriatric trauma patients.  Emergency Medicine 48(1):8-15, 2015.

Marco Catherine A.; Fagan Christopher; Eggers Catherine; Trautman, William; Mann, Dennis; and Olson James E. Self-assessment of hunger among ED patients with abdominal pain: Lack of association with disease severity.  The American Journal of Emergency Medicine 34(1):104-106, 2015.

Marco Catherine A.; Davis, Andrew; Chang, Sylvia; Mann, Dennis; and Olson, James E. Emergency department patient satisfaction: Factors associated with satisfaction with care.  American Journal of Emergency Medicine 33(11):1708-1709, 2015.

Rando, Jessica; Broering, Derek; Olson, James E.; Marco, Catherine; Evans, Stephen B. Intranasal naloxone administration by police first-responders is associated with decreased opioid overdose deaths. American Journal of Emergency Medicine, 33:1201-1204, 2015.

Zheng, Jiaolin; Li, Guangze; Chen, Shuzhen; Chen, Ji; Buck, Joshua; Zhu, Yulan; Xia, Huijing; Lazartigues, Eric; Chen, Yan-fang; and Olson, James E.  Activation of the ACE2/Ang-(1-7)/Mas pathway reduces oxygen-glucose deprivation induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction. Neuroscience, 273:39-51, 2014.

Zheng, Jiaolin; Li, Guangze; Chen, Shuzhen; Wang, Jinju; Olson, James E.; Xia, Huijing; Lazartigues, Eric; Zhu, Yulan; and Chen, Yan-fang.  ACE2/Ang-(1-7)/Mas Axis Protects Brain from Ischemic Injury in both Young and Aged Mice. CNS Neuroscience and Therapeutics, 20:452-459, 2014.

Choe, Katrina; Olson, James, E.; and Bourque, Charles. Taurine release by astrocytes modulates osmosensitive glycine receptor tone and excitability in the adult supraoptic nucleus. Journal of Neuroscience, 32(36):12518-12527, 2012.

Tucker, Brian and Olson, James E. Glutamate receptor-mediated taurine release from the hippocampus during oxidative stress. In: Journal of Biomedical Science, 17(Supplement 1):S10, 2010.

Chen, Shuzhen; Li, Guangze; Zhang, Wenfeng; Wang, Jinju; Sigmund, Curt D. Olson, James E.; and Chen, Yanfang. Ischemia Induced Brain Damage Is Enhanced in Human Renin and Angiotensinogen Double Transgenic Mice. American Journal of Physiology, American Journal of Physiology (Regulatory Integrative and Comparative Physiology), 297(5):R1526-R1531, 2009.

D'Agostino, Dominic P.; Olson, James E.; and Dean, Jay B. Acute hyperoxia increases lipid peroxidation and induces plasma membrane blebbing in human U87 glioblastoma cells. Neuroscience, 159:1011-1022, 2009.

Li, Guangze and Olson, James E. Purinergic activation of anion conductance and osmolyte efflux in cultured rat hippocampal neurons. American Journal of Physiology (Cell Physiology), 295(6):C1550-C1560, 2008.

Stepaniak, Philip C., Hamilton, Glenn C., Olson, James E., Gilmore, Stevan M., Stizza, Denis M., and Beck, Bradley. Physiologic effects of simulated +Gx orbital reentry profiles in hemorrhagic shock modeled primates. Aviation Space and Environmental Medicine, 78(4 Suppl):A14-A25, 2007.

Awards and Other Professional Activities

Dr. Olson receiving the Society for Neuroscience Science Educator Award, 2010
Science Educator Award, Society for Neuroscience, 2010.

Decision Editor, Academic Emergency Medicine, 2008-present.

Society of Academic Emergency Medicine, Program Committee 2007-2012, Awards coordinator 2008-2012.

Society of Academic Emergency Medicine Research committee 2002-2007, chair 2004-2007.

American College of Emergency Physicians, Scientific Research Committee 2002-2015.

Outstanding Achievement in Medical education and Research, Wright State University Academy of Medicine, 2008.

Best Oral Presentation, 16th Annual Society for Neuroscience Midwest Regional Meeting, 2006.

Member, National Institutes of Health: Neurology B and Neurology 3 Study Sections, 1987, 1991, 1996.

Member, National Institutes of Health: Developmental and Cellular Neuroscience Fellowship Grants Study Section, 1999.

Member, National Institutes of Health: Brain Disorders and Clinical Neuroscience Study Sections, 2001 - 2006.

Member, National Institutes of Health: Small Grants for New Investigators to Promote Diversity Study Section, 2015.

Stanford University School of Medicine, Stanford, California Dean's Post-doctoral Fellowship, 1980-1981.

Artistic and Reflective Contributions Selected from 42 Total

Olson, James E. and Singer, Jonathan.  Emeritus professor Spot: Even cajoled, he don’t pull shifts. Academic Emergency Medicine, 20(2):217, 2013.

Olson, James E. and Singer, Jonathan.  A Farmer’s Confession Regarding the Sharecropper’s Daughter. Academic Emergency Medicine, 19(10):1217, 2012.

Olson, James E. and Singer, Jonathan. Those legs made for walkin'. Academic Emergency Medicine, 18(10):1110, 2011.

Olson, James E. and Singer, Jonathan. Art lovers are not all of one mind. Academic Emergency Medicine, 18(5):563, 2011.

Olson, James E. and Singer, Jonathan. A tribute to permanent night people. Academic Emergency Medicine, 17(5):574, 2010.

Singer, Jonathan; Olson, James E.; Olson, Pam; Doerger, Phyllis; and Carson, Stephanie. "Illuminating Silhouettes", An Anthology of poems and photos; LuLu.com, 2010.

Olson, James E. and Singer, Jonathan. Can we prosper in the barren landscape? Academic Emergency Medicine, 17(3):347, 2010.

Olson, James E. and Singer, Jonathan. DPCT: Adding to the cardiac predictive terminology, Academic Emergency Medicine, 16(10):1036, 2009.

Olson, James E. and Singer, Jonathan.  SIRS is not a playful act.  Academic Emergency Medicine, 16(8):813, 2009.

Olson, James E. and Singer, Jonathan. Thoughts from my visit to Salvatore Vicario. Academic Emergency Medicine, 15(7):648, 2008.

Olson, James E. and Singer, Jonathan. At the time of my need, father returns the favor. Academic Emergency Medicine, 15(1):31, 2008.

Olson, James E. and Singer, Jonathan. At the discharge counter. Academic Emergency Medicine, 14(1):73, 2007.

Olson, James E. and Singer, Jonathan I.  Justice before your peers. Academic Emergency Medicine, 13(10):1019, 2006.

Olson, James E. and Singer, Jonathan.  Do not be stranded by signals not perfectly understood.  Annals of Emergency Medicine, 45(5):559, 2005.

Olson, James E. and Singer, Jonathan.  Of shoes and codes and sealing bags. Academic Emergency Medicine, 11(12):1327, 2004.

Olson, James E. and Singer, Jonathan.  The artistry of attenging in the ED. Academic Emergency Medicine, 11(10):1013, 2004.

Olson, James E. and Singer, Jonathan.  Keeping a precious moment between the pages. Academic Emergency Medicine, 11(5):434, 2004.

Olson, James E. and Singer, Jonathan.  Field of study for the retired chair. Academic Emergency Medicine, 11(3):306, 2004.

Personal Interests

Family (always first), Flying (private pilot), Photography, Classical Guitar, Blues Harmonica and Bass.

Education History: 

B.S., Engineering Physics, Cornell University

Ph.D., Biophysics: University of California, Berkeley

Fellowship, Neurology/Neurochemistry: Stanford University

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