Manasi Suchit Halurkar
Bachelor of Pharmacy (2015)
University of Mumbai
Passed with A grade and distinction
Project: Effect of endothelial progenitor cells (EPC) derived exosomes (EXs) on high glucose (HG) plus hypoxia-reoxygenation (H/R) induced injury of human astrocytes.
Advisor: Dr. Ji C. Bihl
Ischemic stroke is one of the leading causes of death worldwide. While diabetes mellitus is one of the risk factors for the occurrence of ischemic stroke. There have been studies reported suggesting that not many patients who suffer from ischemic stroke are able to recover from the same, however the only therapy available cuurently is that of recombinant tissue plasminogen activator (rtPA) the other being endovascular thrombectomy procedure. On the other hand, endothelial progenitor cells (EPCs) are found to be beneficial in term of angiogenesis and recovery in stroke, while the mechanism by which they act is still unkown. However, the EPC-exosomes (EXs), which are the extracellular vesicles released by these cells when under stress, have been found to contain the same biomolecules, that are the mRNA, RNA, miRNA, proteins and lipids, as that of the parent cells. Thus, one possible reason for this recovery by using EPCs is the action of the EXs released by these cells. We are looking at EPC-EXs as novel therapeutic agent for the treatment of ischemic stroke due to diabetes in vitro, using the HG plus H/R model and the human astrocytes cell line.
OVSOT Annual Meeting 2018 (Louiseville, Kentucky)
Best poster award in Master's students category at the OVSOT annual meeting held at University of Louiseville, Kentucky; on 28 November 2018.
Poster title: Effect of EPC-EXs on HG plus H/R induced injury of neurons and astrocytes.