Philippe Sucosky, Ph.D.

Department:
Mechanical & Materials Engineering
Title:
Associate Professor
Address:
Russ Engineering Center 257, 3640 Colonel Glenn Hwy, Dayton, OH 45435-0001

Education

 
  • 1999: B.S., Mechanical Engineering, Ecole Nationale Superieure d'Arts et Metiers, Paris, France
  • 2000: M.S., Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA
  • 2005: Ph.D., Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA
  • 2008: postdoc, Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA

 

Professor Sucosky was born in Nice (France), in 1976. He received his B.S. in mechanical engineering from the Ecole Nationale Supérieure d’Arts et Métiers, Paris, France, in 1996, and his M.S. and Ph.D. in mechanical engineering from the Georgia Institute of Technology, Atlanta, GA, in 2000 and 2005, respectively.

From 2005 to 2008, he was a Postdoctoral Fellow with the Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA. From 2008 to 2015, he was an Assistant Professor with the Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN and the Director of the Multi-Scale Cardiovascular Bioengineering Laboratory. Since 2015, he has been an Associate Professor in Mechanical and Materials Engineering at Wright State University. His research interests are in biofluid mechanics, hemodynamics, cardiovascular mechanobiology, heart valve disease and cardiovascular medical devices.

Dr. Sucosky was a recipient of a Postdoctoral Fellowship from the American Heart Association in 2006, a Young Investigator Award from the International Society for Applied Cardiovascular Biology in 2008, and a CAREER Award from the National Science Foundation in 2011. He is an elected fellow of the American Heart Association and a member of the American Society of Mechanical Engineers and the Biomedical Engineering Society.

Academics

Research statement: 

Prof. Sucosky's interests are in the engineering discipline of fluid mechanics, with application to the mechanobiology of cardiovascular structures. Mechanobiology is an emerging field of science, which describes how mechanical forces affect the biology of living systems. It has provided a new way to think about the function of cells, tissues and organs, and is now considered a potential tool to elucidate disease mechanisms. Mechanobiology requires a multidisciplinary approach in which the detailed description of the mechanical environment and the thorough analysis of its effects on tissue biology are addressed in tandem. Historically, such studies have put more emphasis on the biological description of mechano-sensitive processes in simplified biological models than on the implementation of realistic mechanical stimuli due to the limited knowledge of the native mechanical environment and the challenge to replicate it on intact tissue in the laboratory. The lack of realistic laboratory models that duplicate the native tissue mechanical environment has hampered our understanding of mechano-sensitive disease processes and the development of early diagnosis and therapeutic modalities. Therefore, Prof. Sucosky's primary research interests are in the characterization of the native hemodynamics and the elucidation of the mechano-sensitive response in cardiovascular tissue and medical devices, with a particular focus on valvular disease.
 
Prof. Sucosky's current interests are in:

  • fluid-structure interactions (FSI) in the aortic valve and their relationship to valvular calcification
  • flow abnormalities in the bicuspid aortic valve and their impact on aortopathy
  • flow in hemodialysis vascular access and its role in intimal hyperplasia pathogenesis

While these disorders have been studied for decades, the causality between hemodynamics and pathogenesis has never been rigorously established. Prof. Sucosky's Multi-Scale Cardiovascular Bioengineering Laboratory (MSCBL) has invested in the development of new approaches addressing the fluid mechanical and biological aspects of those disorders at the same level of depth, and is one of the few with such expertise.

Professional

Publications: 

1.    Cao K, Sucosky P. Three-Dimensional Prediction of Regional and Temporal Wall Shear Stress Characteristics on Aortic Valve Leaflets. Computer Methods in Biomechanics and Biomedical Engineering. 2015; http://dx.doi.org/10.1080/10255842.2015.1052419

2.    Cao K, Sucosky P. Effect of Bicuspid Aortic Valve Cusp Fusion on Aorta Wall Shear Stress: Preliminary Computational Assessment and Implication for Aortic Dilation. World Journal of Cardiovascular Diseases. 2015; 5: 129-40. http://dx.doi.org/10.4236/wjcd.2015.56016

3.    Sun L, Sucosky P. Bone Morphogenetic Protein-4 and Transforming Growth Factor-Beta1 in Acute Valvular Response to Supra-Physiologic Hemodynamic Stresses. World Journal of Cardiology. 2015; 7: http://dx.doi.org/331-43. 10.4330/wjc.v7.i6.331

4.    Atkins SK, Sucosky P. The Etiology of Bicuspid Aortic Valve Disease: Focus on Hemodynamics. World Journal of Cardiology. 2014; 6: 1227-33. http://dx.doi.org/10.4330/wjc.v6.i12.1227

5.    Seaman C, McNally A, Biddle S, Jankowski L, Sucosky P. Generation of Simulated Calcific Lesions in Valve Leaflets for Flow Studies. Journal of Heart Valve Disease. 2015; 24: 115-125.

6.    Seaman C, Sucosky P. Anatomic Orifice Area, Effective Orifice Area and Pressure Recovery in the Bicuspid Aortic Valve. Echocardiography. 2014; 31: 1028. http://dx.doi.org/ 10.1111/echo.12720

7.    McNally A, Akingba AG, Robinson EA, Sucosky P. Novel Modular Anastomotic Valve Device for Hemodialysis Vascular Access: Design and Preliminary Computational Hemodynamic Assessment. Journal of Vascular Access. 2014; 15: 448-460. http://dx.doi.org/10.5301/jva.5000284

8.    Atkins SK, Cao K, Rajamannan NM, Sucosky P. Bicuspid Aortic Valve Hemodynamics Induces Abnormal Medial Remodeling in Porcine Ascending Aortas. Biomechanics and Modeling in Mechanobiology. 2014; 13: 1209-25. http://dx.doi.org/10.1007/s10237-014-0567-7

9.    Seaman C, Akingba AG, Sucosky P. Steady Flow Hemodynamic and Energy Loss Measurements in Normal and Simulated Calcified Tricuspid and Bicuspid Aortic Valves. Journal of Biomechanical Engineering. 2014; 136. http://dx.doi.org/10.1115/1.4026575

10. Sun L, Rajamannan NM, Sucosky P. Defining the Role of Fluid Shear Stress in the Expression of Early Signaling Markers for Calcific Aortic Valve Disease. PLOS ONE . 2013; 8: e84433. http://dx.doi.org/10.1371/journal.pone.0084433

11. Sun L, Chandra S, Sucosky P. Ex Vivo Evidence for the Contribution of Hemodynamic Shear Stress Abnormalities to the Early Pathogenesis of Calcific Bicuspid Aortic Valve Disease. PLOS ONE. 2012; 7: e48843. http://dx.doi.org/10.1371/journal.pone.0048843

12. Chandra S, Rajamannan NM, Sucosky P. Computational assessment of bicuspid aortic valve wall-shear stress - Implications for calcific aortic valve disease. Biomechanics and Modeling in Mechanobiology. 2012; 11: 1085-1096. http://dx.doi.org/10.1007/s10237-012-0375-x

13. Balachandran K, Sucosky P, Yoganathan AP. Hemodynamics and Mechanobiology of Aortic Valve Inflammation and Calcification. International Journal of Inflammation. 2011; 263870. http://dx.doi.org/10.4061/2011/263870

14. Sun L, Rajamannan NM, Sucosky P. Design and Validation of a Novel Bioreactor to Subject Aortic Valve Leaflets to Side-Specific Shear Stress. Annals of Biomedical Engineering. 2011; 39: 2174-2185.  http://dx.doi.org/10.1007/s10439-011-0305-6

15. Hoehn D, Sun L•, Sucosky P. Role of Pathologic Shear Stress Alterations in Aortic Valve Endothelial Activation. Cardiovascular Engineering and Technology. 2010; 1: 165-178.  http://dx.doi.org/10.1007/s13239-010-0015-5

16. Balachandran K, Sucosky P, Jo H, Yoganathan AP. Elevated Cyclic Stretch Induces Aortic Valve Calcification in a Bone Morphogenic Protein Dependent Manner. American Journal of Pathology. 2010; 177: 49-57. http://dx.doi.org/10.2353/ajpath.2010.090631

17. Dasi LP, Sucosky P, de Zelicourt D, Sundareswaran K, Jimenez J, Yoganathan AP. Advances in cardiovascular fluid mechanics: bench to bedside. Annals of the New York Academy of Sciences. 2009; 1161: 1-25. http://dx.doi.org/10.1111/j.1749-6632.2008.04320.x

18. Balachandran K, Sucosky P, Jo H, Yoganathan AP. Elevated Cyclic Stretch Alters Matrix Remodeling in Aortic Valve Cusps - Implications for Degenerative Aortic Valve Disease? American Journal of Physiology - Heart and Circulatory Physiology. 2009; 296: H756-64. http://dx.doi.org/10.1152/ajpheart.00900.2008

19. Dasi LP, Simon HA, Sucosky P, Yoganathan AP. Fluid Mechanics of Artificial Heart Valves. Clinical and Experimental Pharmacology and Physiology. 2009; 36: 225-237. http://dx.doi.org/10.1111/j.1440-1681.2008.05099.x

20. Sucosky P, Elhammali A, Balachandran K, Jo H, Yoganathan AP. Altered Shear Stress Stimulates Upregulation of Endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-β1-Dependent Pathway. Arteriosclerosis, Thrombosis and Vascular Biology. 2009; 29: 254-260. http://dx.doi.org/10.1161/ATVBAHA.108.176347

21. Bilgen B, Uygun K, Bueno EM, Sucosky P, Barabino GA. Tissue Growth Modeling in a Wavy-Walled Bioreactor. Tissue Engineering Part A. 2008; 15: 761-771. http://dx.doi.org/10.1089/ten.tea.2008.0078

22. Dasi LP, Sucosky P, Yoganathan AP. Letter by Dasi et al. regarding article, “Effect of chronotropy and inotropy on stitch tension in the edge-to-edge mitral repair”. Circulation 2008; 118: e78. http://dx.doi.org/10.1161/CIRCULATIONAHA.107.750695

23. Sucosky P, Dasi LP, Paden ML, Fortenberry JD, Yoganathan AP. Assessment of Current Continuous Hemofiltration Systems and Development of a Novel Accurate Fluid Management System for Use in Extracorporeal Membrane Oxygenation. Journal of Medical Devices. 2008; 2: 035002-1-035002-8. http://dx.doi.org/10.1115/1.2952818

24. Sucosky P, Padala M, Elhammali A, Balachandran K, Jo H, Yoganathan AP. Design of an Ex Vivo Culture System to Investigate the Effects of Shear Stress on Cardiovascular Tissue. Journal of Biomechanical Engineering. 2008; 130: 035001-035008. http://dx.doi.org/10.1115/1.2907753

25. Balachandran K, Konduri S, Sucosky P, Jo H, Yoganathan AP. An ex vivo study of the biological properties of porcine aortic valves in response to circumferential cyclic stretch. Annals of Biomedical Engineering. 2006; 34: 1655-1665. http://dx.doi.org/10.1007/s10439-006-9167-8

26. Bilgen B, Sucosky P, Neitzel GP, Barabino GA. Flow characterization of a wavy-walled bioreactor for cartilage tissue engineering. Biotechnology and Bioengineering. 2006; 95: 1009-1022. http://dx.doi.org/10.1002/bit.20775

27. Sucosky P, Osorio DF, Brown JB, Neitzel GP. The fluid mechanics of a spinner-flask bioreactor. Biotechnology and Bioengineering. 2004; 85: 34-46. http://dx.doi.org/10.1002/bit.10788

 

Awards/Recognition: 
  • 10/2013: Elected Fellow of the American Heart Association (Council on Basic Cardiovascular Sciences)
  • 1/2012: Faculty Early CAREER Award, National Science Foundation
  • 9/2008: Young Investigator Award, International Society for Applied Cardiovascular Biology
  • 1/2006: Postdoctoral Fellowship Award, American Heart Association
  • 8/1999: Silver Medal, Ecole Nationale Supérieure d'Arts et Métiers
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