Ryan B Griggs, Ph.D.

Department:
NeuroSci Cell Bio Physiology-SOM
Title:
Postdoctoral Researcher
Address:
NEC Building 378, 3640 Colonel Glenn Hwy, Dayton, OH 45435
Curriculum Vitae: 
Education History: 

current   Postdoctoral Researcher in Neuroscience – Wright State University – Dr. Keiichiro Susuki (advisor)

2015       PhD in Physiology – University of Kentucky – Dr. Bradley K. Taylor (advisor)

2009       MS in Biotechnology – University of Pennsylvania

2007       BS in Unified Science – Drexel University

 

Academics

Teaching: 

2019                     Senior Seminar in Neurodegeneration (BIO 4920) – Adjunct Faculty, Wright State University

2017                     Scientific Literacy for the 21st Century (SM 1010) – Shadowed Instructor, 1 class, Wright State University

2014 – 2015        Concepts of Biology Laboratory I: Cell & Molecular (BIO 151L) – Primary Instructor, 6 sections

                              General Biology Laboratory I (BIO 101L) – Primary Instructor, 1 section

                              University of Dayton, Department of Biology - Adjunct Faculty, 2 semesters

2012 – 2013        Human Anatomy & Physiology Lab (BIO 137) – Primary Instructor, 2 semesters

                              Bluegrass Community and Technical College – Department of Natural Sciences

                              Critical Scientific Readings (IBS 610) – Senior Student Discussion Leader, 1 semester

                              University of Kentucky – Integrated Biomedical Sciences First-Year Curriculum

2012 – 2013       Human Physiology (PGY 206 / PGY 412G / PGY 502) – Tutor, 2 semesters

                             University of Kentucky – Department of Physiology

2011 – 2012       Elementary Human Physiology Recitation (PGY 207) – Primary Instructor, 3 semesters

                             University of Kentucky – Biology, Nursing, and Physical Therapy Curriculums

2011                     Integrated Biomedical Sciences Curriculum Enhancement Committee – Student Member

                              University of Kentucky College of Medicine

Research statement: 

Proper function of the peripheral and central nervous systems requires specialized structures within neurons. These structures, the axon initial segment and nodes of Ranvier, are formed, maintained, and altered by mechanisms at both the individual neuron level and by other supporting cells such as oligodendrocytes, Schwann cells, astrocytes, and microglia. In patients living with diseases such as diabetes, multiple sclerosis, Alzheimer's, and chronic pain the morphological appearance of the axon initial segment and/or nodes of Ranvier and associated paranodal and juxtaparanodal structures is altered. Many studies suggest that these changes in appearance lead to functional deficits, which presumably contribute to debilitating complications like neuropathic pain, cognitive dysfunction, learning and memory deficits, and reduced neuromuscular control. Our goal is to determine how these morphological and functional changes in specialized excitable domains within neurons occur, and develop therapeutic strategies that reduces their contribution to neurological diseases. To accomplish this goal, we use a combination of research approaches that include transgenic mice, molecular biology, fluorescent and electron microscopy, behavioral pharmacology, primary neuron culture, calcium imaging, and electrophysiology in the form of in vivo motor nerve conduction, ex vivo sensory nerve conduction, and in vitro multi-electrode array recordings.

 

Professional

Publications: 

Up to date list of publications can be found on Pubmed.

Original Research

  • Griggs RB, Santos DF, Laird DE, Doolen S, Donahue RR, Wessel CR, Fu W, Sinha GP, Wang P, Zhou J, Brings S, Fleming T, Nawroth PP, Susuki K, Taylor BK. Methylglyoxal and a spinal TRPA1-AC1-Epac cascade facilitate pain in the db/db mouse model of type 2 diabetes. Neurobiology of Disease. 2019 Feb 23, 127:76-86. PMID: 30807826
  • Susuki K, Zollinger DR, Chang K-J, Zhang C, Huang CY-M, Tsai C-R, Galiano MR, Liu Y, Benusa SD, Yermakov LM, Griggs RB, Dupree JL, Rasband MN. Glial βII spectrin contributes to paranode formation and maintenance. Journal of Neuroscience. 2018 Jul 4; 38(27):6063-6075. PMID: 29853631
  • Yermakov LM, Drouet DE, Griggs RB, Elased KM, Susuki K. Type 2 diabetes leads to axon initial segment shortening in db/db mice. Frontiers in Cellular Neuroscience. 2018 June 8; 12:146 PMID: 29937715
  • Griggs RB, Yermakov YM, Drouet DE, Nguyen DVM, Susuki K. Methylglyoxal disrupts paranodal axoglial junctions via calpain activation. ASN Neuro. 2018 Jan-Dec; 10:1759091418766175. PMID: 29673258
  • Griggs RB, Laird, DE, Donahue RR, Fu W, Taylor BK. Methylglyoxal requires AC1 and TRPA1 to produce pain and spinal neuron activation. Frontiers in Neuroscience. 2017 December 6; 11:679. PMID: 29270106
  • Griggs RB, Donahue RR, Adkins BG, Anderson KL, Thibault O, Taylor BK. Pioglitazone inhibits the development of hyperalgesia and sensitization of spinal nociresponsive neurons in type 2 diabetes. Journal of Pain. 2016 March; 17(3):359-73. PMID: 26687453
  • Griggs RB, Bardo MT, Taylor BK. Gabapentin alleviates affective pain after traumatic nerve injury. Neuroreport. 2015 June 17; 26(9):522-7. PMID: 26011387
  • Griggs RB, Donahue RR, Morgenweck J, Grace PM, Sutton A, Watkins LR, Taylor BK. Pioglitazone rapidly reduces neuropathic pain through astrocyte and non-genomic PPARγ mechanisms. Pain. 2015 March; 56(3):469-82. PMID: 25599238
  • Maimaiti S, DeMoll C, Anderson KL, Griggs RB, Taylor BK, Porter NM, Thibault O. Short-lived diabetes in the young-adult ZDF rat does not exacerbate neuronal Ca2+ biomarkers of aging. Brain Research. 2015 September 24; 1621:214-21. PMID: 25451110
  • Morgenweck J, Griggs RB, Donahue RR, Zadina JE, Taylor BK. PPARγ activation blocks development and reduces established neuropathic pain in rats. Neuropharmacology. 2013 July; 70:236-46. PMID: 23415633

Reviews & Book Chapters 

  • Yermakov LM, Hong LA, Drouet DE, Griggs RB, Susuki K. “Functional domains in myelinated axons.” Myelin – Basic and Clinical Advances (Editors: Sango K, Yamauchi J, Ogata T, Susuki K). Springer 2019 Chapter 7. In press
  • Griggs RB, Yermakov LM, Susuki K. Formation and disruption of functional domains in myelinated CNS axons. Neuroscience Research. 2017 March; 116:77-87. PMID: 27717670.
Professional Affiliations/Memberships: 

Society for Neuroscience

Ohio Miami Valley Society for Neuroscience chapter

 

Awards/Recognition: 

Trainee Professional Development Award - 48th Annual Meeting - Society for Neuroscience (2018)

Best Postdoctoral Researcher Poster - 15th Annual Neuroscience Day, Ohio Miami Valley Society for Neuroscience (2018) - The diabetes metabolite methylglyoxal disrupts the axon initial segment 

Best Graduate Student Poster - 31st Annual Spring Neuroscience Day, Bluegrass Society for Neuroscience (2015) - Methylglyoxal produces pain in type 2 diabetes via TRPA1 and AC1

F31 Individual Fellowship – NIH NINDS NS083292 (2013-2015) - Methylglyoxal and TRPA1 contribution to neuropathic pain in type 2 diabetes 

T32 Institutional Fellowship – NIH NINDS NS077889 (2012-2013) - Neurobiology of CNS Injury & Repair

 

Is this you? Log in to update your profile.