Kavya Shaj

Graduate Student
Student college:
School of Medicine
Student major:
Pharmacology + Toxicology
Curriculum Vitae: 
Education History: 

Doctor of Pharmacy (PharmD), Grade A with Subject distinction

Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, Maharashtra, India.

Pre-University Degree in Science: Biology and Mathematics, Grade A

    South Indian Educational Society’s College of Arts and Science, Mumbai, India.

 

Academics

Research statement: 

Advisor : Dr. Michael Kemp ( https://people.wright.edu/mike.kemp ) 

Co-Advisor : Dr. Jeffrey B Travers ( https://people.wright.edu/jeffrey.travers )

Everyone of us are exposed to different environmental toxins and stress on a daily basis and genotoxic effect of sunlight is a most prevalent one. But our body system is capable of handling such insults by different mechanisms and one of them is the DNA Damage-Repair Mechanisms.Genotoxins induce formation of adducts on genomic DNA which the Repair Mechanisms try to remove giving rise to single or double strand breaks in DNA.Various checkpoint signalings identify these breaks and help cells to cope up by regulating the cell cycle. Ataxia Telangiectasia and Rad-3 related protein (ATR) and Ataxia Telangiectasia Mutated (ATM) kinases are the ones activated by presence of single strand DNA breaks which leads to cell cycle arrest.

My research is focused on the ATR kinase role in response to DNA Damage by ultraviolet light ( UV ) in non-cycling,quiescent and senescent cells broadly called as non-replicating cells. The above mentioned ATR kinase role is established with models using cycling cells whereas most cells in our body are in non- cycling / non- replicating state. Previous work by my advisor has shown opposite effects of ATR kinase in replicating and non replicating cells. Also, it was seen that the ATR kinase activation was due to replication stress in replicating cells whereas it was due to transcription stress in non- replicating cells. I will be looking further into the ATR kinase activation and function in non - replicating cells when exposed to UVB by using in- vitro and ex- vivo models. This could give insights into the possible implication of ATR inhibitors given as adjuvant in chemotherapy in development of mutagenesis and secondary cancer in presence of genotoxic chemicals like cisplatin or even UV. 

Professional

Publications: 

2017-July
“Toxicological Pattern of Poisonings in Urban Hospitals of Western India”

Journal of Young Pharmacists (https://www.jyoungpharm.org/article/1010)

2017-August
“Psychosocial Factors as Risk Factor in Suicidal Poisoning: A Cross-Sectional Study."

Asian Journal of Pharmaceutical and Clinical Research (https://innovareacademics.in/journals/index.php/ajpcr/article/view/18983)

2017-August
“Treatment Approaches for Management of Poisonings in India”

Annals of Public Health (https://www.jscimedcentral.com/PublicHealth/publichealth-4-1068.pdf)

 

Awards/Recognition: 

Student Speaker
The Quality Improvement Program on Clinical Pharmacy and Skill Development sponsored by AICTE India. February 2017

Title: “ADR Identification, Reporting, and Documentation. Breakthrough Pharmacovigilance Program in India”

Winner
Best Research Paper Presentation, National Conference- PHARMACON 2016.India

 Title: “Pediatric Poisoning: Clinical Pattern and Therapeutic Strategy”

Winner
EUREKA 2015 State Level Innovative Project. Maharashtra,India.

Title: “Impact of Pregnancy Induced Hypertension and its treatment on Fetal Growth.”

Winner
Oral Paper Presentation, National Pharmacy Week 2016.Indian Pharmaceutical Association.

Title: “Prevalence of Diabetes in India and Pharmacist Interventions Worldwide: A Systematic Review”

Runner Up
Oral Paper Presentation, National Pharmacy Week 2015.Indian Pharmaceutical Association.

Title: “Pharmacist as a Healthcare Professional; Role in National Tuberculosis Control Program and Vaccination.”

Runner Up
Oral Paper Presentation, National Pharmacy Week 2014.Indian Pharmaceutical Association.

Title: “Pharmacist in Public Health: Impact of National Health Programs.”

 

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