Please also see https://andrewvosslab.org/.
- Postdoctoral Fellow, Physiology, UCLA David Geffen School of Medicine (Advisors: Ernest M. Wright and Julio L. Vergara)
- Ph.D., Pharmacology and Toxicology, University of California, Davis (Advisor: Isaac N. Pessah of School of Vet Med)
- Teaching Credential, National University, Sacramento, California
- B.S., Biochemistry, University of California, Davis
- Transfer Student, American River Community College, Sacramento, California
Wright State University
- Exercise Physiology (BIO3530)
- Neuromuscular Physiology (BIO4020)
- Cell Biology & Physiology (BIO4030)
- Cell Biology (BIO7300)
Cal Poly Pomona
- Human Physiology (BIO235/L formerly ZOO235/L)
- Neuromuscular Physiology (BIO575)
- Animal Models & Muscle Disease (BIO575)
- Basic Biology (BIO115)
My laboratory examines neuromuscular and skeletal muscle physiology using electrophysiology, muscle force measurements, pharmacology, biochemistry, and optics. We are currently working on muscle dysfunction in Huntington's disease, myotonia, and muscular dystrophy. With some outstanding collaborators, our research on individual muscle fibers and molecular mechanisms extends to whole animal behavior and the clinic. Collaborators include Drs. Mark Rich, Ulas Sunar, and Hong-Mei Ren of Wright State University, Dr. Robert Talmadge of Cal Poly Pomona, and Dr. Sandra Kostyk of the Ohio State University Movement Disorders Division.
We always want to hear from students interested in the lab.
Publications (*Undergraduate Student, **Graduate Student)
- Xueyong Wang, Murad Nawaz*, Chris Dupont**, Jessica Meyers**, Steven R.A. Burke, Roger Bannister, Brent Foy, Andrew A. Voss, Mark M. Rich. The role of Action Potential Changes in Depolarization-Induced Failure of Excitation Contraction Coupling in Mouse Skeletal Muscle. eLife 2022;11:e71588.
- Briana Simpson**, Mark M. Rich, Andrew A. Voss, Robert J. Talmadge. Acetylcholine receptor subunit expression in Huntington's disease mouse muscle. Biochemistry and Biophysics Reports. 2021 Volume 28, December, 101182.
- Daniel R. Miranda**, Andrew A. Voss, and Roger A. Bannister. Into the spotlight: RGK proteins in skeletal muscle. Cell Calcium. 2021, September, Volume 98, 102439.
- Jessica H Myers**, Kirsten Denman**, Chris DuPont**, Ahmed A Hawash**, Kevin R Novak**, Andrew Koesters, Manfred Grabner, Anamika Dayal, Andrew A Voss, Mark M Rich. The mechanism underlying transient weakness in myotonia congenita. eLife 2021;10:e65691.
- Shannon H. Romer, Sabrina K Metzger**, Kristiana Peraza*, Matthew C. Wright*, D. Scott Jobe**, Long-Sheng Song, Mark M Rich, Brent D Foy, Robert J Talmadge and Andrew A. Voss (corr auth). A mouse model of Huntington's disease shows altered ultrastructure of transverse tubules in skeletal muscle fibers. Journal of General Physiology. 2021 April Vol. 153, Issue 4.
- This article was highlighted by the journal with a Commentary, Journal of General Physiology (2021) 153 (6): e202012843.
- Sandhya Ramani Sattiraju, Abdulrahman Jama**, Abdullah A. Alshudukhi**, Nicholas Edward Townsend, Daniel Reynold Miranda**, Rebecca R Reese, Andrew A. Voss, Hongmei Ren. Loss of membrane integrity drives myofiber death in lipin1deficient skeletal muscle. Physiological Reports. 2020, Vol 8 (20) e14620.
- Daniel R. Miranda**, Eric Reed**, Abdulrahman Jama**, Michael Bottomley, Hongmei Ren, Mark M. Rich, and Andrew A. Voss (corr auth). Mechanisms of altered skeletal muscle action potentials in the R6/2 mouse model of Huntington's disease. American Journal of Physiology – Cell Physiology. 2020, 319 (1) July, C218-C232.
- Chris Dupont, Kevin Novak**, Kirsten Denman, Jessica H. Myers**, Jeremy M. Sullivan, Phillip V, Walker II**, Nicklaus L. Brown, David R. Ladle, Laurent Bogdanik, Cathleen M. Lutz, Andrew A. Voss, Charlotte J. Sumner, and Mark M. Rich. TRPV4 antagonism prevents mechanically induced myotonia. Annals of Neurology. 2020 Vol. 88, No. 2, 297–308.
- Xueyong Wang, Steven R.A. Burke**, Robert J. Talmadge, Andrew A. Voss (co-corr auth), and Mark M. Rich (co-corr auth). Depressed neuromuscular transmission causes weakness in mice lacking BK potassium channels. Journal of General Physiology. 2020, 152 (5): e201912526.
- This article was highlighted by the journal with a Research News article, Journal of General Physiology. 2020, 152 (5): e202012616.
- Faculty Opinions (formerly f1000Prime) recommendation (https://f1000.com/prime/737867914)
- Sabrina Metzger**, Chris Dupont, Andrew A. Voss, and Mark M. Rich. The central role of subthreshold currents in myotonia. Annals of Neurology. 2020 Vol. 87, No. 2, 175–183.
- Chris Dupont, Kirsten S. Denman, Ahmed A. Hawash**, Andrew A. Voss, and Mark M. Rich. Treatment of Myotonia Congenita with Retigabine in Mice. Experimental Neurology. 2019 Vol. 315, 52-59.
- Steven R.A. Burke**, Eric J. Reed**, Shannon H. Romer, and Andrew A. Voss (corr auth). Levator Auris Longus Preparation for Examination of Mammalian Neuromuscular Transmission Under Voltage Clamp Conditions. J. Vis. Exp. (135), e57482, doi:10.3791/57482 (2018).
- Ahmed Hawash, Andrew A. Voss (co-corr auth), and Mark M. Rich (co-corr auth). Inhibiting persistent inward sodium currents prevents myotonia. Annals of Neurology. 2017 Vol. 82, No. 3, 385-395.
- Ahmad Khedraki**, Eric J. Reed**, Shannon H. Romer, Qingbo Wang, William Romine, Mark M. Rich, Robert J. Talmadge, and Andrew A. Voss (corr auth). Depressed Synaptic Transmission and Reduced Vesicle Release Sites in Huntington's Disease Neuromuscular Junctions. Journal of Neuroscience. 2017 Aug 23, 37(34):8077-91.
- Featured on the cover of the Aug. 23 issue.
- Daniel R. Miranda**, Monica Wong**, Shannon H. Romer, Cynthia McKee*, Gabriela Garza-Vasquez*, Alyssa C. Medina*, Volker Bahn, Andrew D. Steele, Robert J. Talmadge, and Andrew A. Voss (corr auth). Progressive Cl− channel defects reveal disrupted skeletal muscle maturation in R6/2 Huntington’s mice. Journal of General Physiology. 2017 Jan;149(1) 55-74.
- Highlighted with a Commentary, Martin Skov and Robert T. Dirksen. Trojan triplets: RNA-based pathomechanisms for muscle dysfunction in Huntington’s disease. Journal of General Physiology. 2017 Jan;149(1) 49-53.
- Donald Beqollari, Christian F. Romberg, Gabriella Dobrowolny, Martina Martini, Andrew A. Voss, Antonio Musarò, and Roger A. Bannister. Progressive impairment of CaV1.1 function in the skeletal muscle of mice expressing a mutant type 1 Cu/Zn superoxide dismutase (G93A) linked to amyotrophic lateral sclerosis. Skeletal Muscle. 2016 Jun 23;6:24.
- **Christopher W. Waters, *Grigor Varuzhanyan, Robert J. Talmadge, and Andrew A. Voss (corr auth). Huntington’s disease skeletal muscle is hyperexcitable owing to chloride and potassium channel dysfunction. Proceedings of the National Academy of Sciences. 2013 May;110(22): 9160-65.
- Faculty of 1000 Recommendation (https://f1000.com/prime/723892806)
- Charles S. Hummel, C Lu, Donald D. Lu, Bruce Hirayama, Andrew A. Voss and Ernest M. Wright. Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. American Journal of Physiology – Cell Physiology. 2011 Jan;300(1):C14-21.
- Faculty of 1000 Recommendation (https://f1000.com/prime/6016957)
- Andrew A. Voss (corr auth). Extracellular ATP inhibits chloride channels in mature mammalian skeletal muscle by activating P2Y1 receptors. Journal of Physiology-London. 2009 587: 5739-5752.
- Andrew A. Voss, Paul D. Allen, Isaac N. Pessah and Claudio F. Perez. Allosterically coupled calcium and magnesium binding sites are unmasked by ryanodine receptor chimeras. Biochemical and Biophysical Research Communications. 2008 Feb;366: 988-93.
- Andrew A. Voss (corr auth), Ana Diez-Sampedro, Bruce Hirayama, Donald D.F. Loo and Ernest M. Wright. Imino sugars are potent agonists of the human glucose sensor SGLT3. Molecular Pharmacology. 2007 Feb;71(2):628-634.
- Jun Gao, Andrew A. Voss, Isaac N. Pessah, Fredine Lauer, Trevor Penning and Scott W. Burchiel. Ryanodine receptor-mediated rapid increase in intracellular calcium induced by 7,8-benzo(a)pyrene quinone in human and murine leukocytes. Toxicological Sciences. 2005 Oct;87(2):419-426.
- Andrew A. Voss, Jozsef Lango, Michael Ernst-Russell, Dexter Morin and Isaac N. Pessah. Identity of redox-sensitive hyperreactive cysteines within ryanodine receptor type 1. The Journal of Biological Chemistry. 2004 Aug;279(33):34514-20.
- Claudio F. Perez, Andrew A. Voss, Isaac N. Pessah and Paul D. Allen. RyR1/RyR3 chimeras reveal that multiple domains of RyR1 are involved in skeletal-type E-C coupling. Biophysical Journal. 2003 Apr;84(4):2655-63.