Jaime E Ramirez-Vick, Ph.D.

Department:
Biomed Indust & Human Factor Engr
Title:
Professor
Address:
Russ Engineering Center 207, 3640 Colonel Glenn Hwy, Dayton, OH 45435-0001

Jaime E. Ramirez-Vick is Professor of Biomedical Engineering at the Wright State University. He has graduate and undergraduate degrees in Chemical Engineering from University of Puerto Rico – Mayaguez and Arizona State University, with postdoctoral training at the Lawrence Berkeley National Laboratory and the Cancer Center of the University of California – San Francisco.  He is co-founder of two microarray-based diagnostic companies in northern California, Iris Biotechnologies and Daedalus Biotechnologies. As technical lead of the companies he was awarded seventeen patents for their core technologies. Dr. Ramirez-Vick is member of the Editorial Board of ten peer-reviewed journals and is ad hoc editor in sixteen others. He also co-authored a textbook titled Bioseparation Process Science.

ACADEMICS

FALL:

  • BME 3211 - Human Biomechanics I
  • BME 6010 - Ethics in Engineering Research and Practice
  • BME 7521 - Advanced Biotransport
  • EGR 7910 - MEIE Project I

SPRING:

  • IHE 6410 - Technology-Based Ventures
  • IHE 6420 - Innovation & Entrepreneurship Seminar Series
  • BME 6421 - Biotransport
  • BME 7980 - Tissue Engineering & Regenerative Medicine
  • BME 7530 - Nanomedicine Fundamentals
  • EGR 7920 - MEIE Project II

 

Research Interests: Nanomedicine in the development of multifunctional nanostructures for cancer detection and treatment, role of mesenchymal stem cells (MSCs) in metastasis,  macrophage modulation during inflammation for ischemic and chronic wound tissue regeneration, regenerative medicine using MSCs in the development of biomimetic 3D scaffolds and the study of their differentiation using biophysical stimulation, and electrochemical nanostructured biosensors for protein and nucleic acid cancer biomarker detection. 

Projects:

Bone Tissue Engineering

  1. Effect of Dimensionality on In Vitro Growth Environment and Mesenchymal Stem Cell Function
  2. Parametric study of biophysical stimulation to control mesenchymal stem cell differentiation in 3D
  3. Effect of crosslinking and retinoic acid in MSC differentiation using electrospun collagen-pullulan
  4. Directing mesenchymal stem cell commitment under microgravity

Wound Healing

  1. Targeting inflammation for skin regeneration on chronic ulcers using a MSC delivery patch
  2. Multifunctional nanomedical reconstituted HDL formulation for targeting polymicrobial biofilms
  3. Ex vivo diabetic wound model for nanomedicine drug targeting
  4. Targeting Biofilms in Wound Infections in United States Military Trauma Patients

Cardiovascular Tissue Engineering & Nanomedicine

  1. Targeting foam cell capacity to uptake and release cholesterol ester as a strategy to dissolve atherosclerotic plaques
  2. Macrophage transdifferentiation to osteoclasts as a treatment for vascular calcification
  3. Targeting macrophages in calcified artery using immunoliposomes
  4. Effect of retinoic acid on elastin production of soft muscle cells on electrospun PCL-gelatin scaffolds
  5. Microfluidic in vitro model for drug-induced vascular damage
  6. 3D engineered artery model for in vitro atherosclerosis nanomedical drug development
  7. Ex vivo artery model for atherosclerosis nanomedical drug development
  8. Targeting fibrosis to induce cardiac tissue regeneration using a gene-activated MSC delivery patch

Cancer Nanomedicine

  1. Microfluidic device to make rHDL nanoparticles
  2. Time-staggered targeted delivery of siRNA and docetaxel to treat drug-resistant prostate cancer
  3. Treatment of renal cell carcinoma by autophagy modulation using targeted graphene oxide-chloroquine nanoconjugates
  4. Treatment of drug-resistant lung cancer by targeted delivery of graphene oxide-chloroquine/cisplatin nanoconjugates through autophagy modulation
  5. Targeting Triple-Negative Breast Cancer through Synthetic Lethal Interactions

Students:

PhD

Anson Jacob Oommen - CTE&N 6

 

MS BME

Alyaa Isam Aldebs - BTE 2 (Graduated Spring 2018)

Kaivon Derek Assani - WH 1 (Graduated Summer 2018)

Wendy Fisher - CN 1

Anson Jacob Oommen - CTE&N 5 (Graduated Spring 2019)

Kaveh Stephan Sanaei - CTE&N 4 (Graduated Spring 2019)

Fatema Tuj (Camila) Zohora - BTE 1 (Graduated Summer 2018)

Ben Wright - CTE&N 6

 

MS Biological Sciences

Imtiaz Karim Rony - BTE 1 (Graduated Summer 2018)

 

MD

Ryan Gabbard - CTE&N 4

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