James B. Lucot, PhD

Professor Emeritius, Pharmacology/Toxicology

In retirement effective July 1, 2015.  I will retain space within the department to continue professional service.

Research background

  • Intersection of toxicology and neuroscience at the level of behavior and neurochemistry
  • Applying neurobehavioral assessment, neurochemical analysis and measurement of catecholamines in urine to characterize animal models of a wide range of disorders

My research approach was to evaluate the interactions between behavior, drugs, and brain chemistry. This approach provided the flexibility to undertake a wide range of projects, to pursue interesting findings, and join in collaborative research. The laboratory  worked with multiple researchers to characterize knockout models using the research techniques available in my laboratory.   These studies expanded the knowledge to be gained from such models without requiring additional subjects because they can be conducted in the same animals being used for the primary purpose of the experiment.  The results extended the knowledge base, raised new hypothesis and generated additional components to grant proposals based on the results.  The approach was also  used to provide standardized proof of efficacy for tests of novel therapies.

Earlier work involved Gulf War Illness, development of a novel neuroprotectant against nerve agent status epilepticus-induced neurodegeneration and resolved and refined a new approach to treatment of nausea and vomiting.

Selected Publications

Lucot, J.B. Antiemetic effects of flesinoxan in cats: Comparisons with 8-hydroxy-2-(di-n-propylamine) tetralin. Eur. J. Pharmacol., 253:53-60, 1994.

Dubovicky, M., S. Paton, M. Morris, M. Mach, J.B. Lucot. Effects of combined exposure to pyridostigmine bromide and shaker stress on acoustic startle response, pre-pulse inhibition and open field behavior in mice. J. Appl. Tox, 27:276-283, 2007.

Mach, M., R.D. Grubbs, W.A. Price, M. Nagoaka, M. Dubovicky and J.B. Lucot. Delayed effect of subacute low-dose exposure to sarin combined with chronic intermittent shaker stress in mice. J. Appl. Tox., 14:28(2) 132-129, 2007.

Mauck, B.S., S.J.Paton, J.B. Lucot, R.D. Grubbs. Subcutaneous exposure to carbamate acetycholinesterase inhibitors does not induce apoptosis in mouse brain. J. Med. Chem. Biol. Rad. Defense, 6, 2008.

Garrett, T.L., C.M. Rapp, R.D. Grubbs, J.J. Schlager, and J.B. Lucot. A murine model for sarin exposure using the carboxylesterase inhibitor CBDP. Neurotoxicology, 2010, In press.

Sharma, A.N, K.M. Elased, T.L. Garrett, J.B. Lucot. Neurobehavioral deficits in db/db diabetic mice. Physiol. Behav., 2010, In Press.
Mauck, B., J.B. Lucot, S. Paton, R.D. Grubbs. Cholinesterase Inhibitors and Stress: Effects on Brain Muscarinic Receptor Density in Mice. Neurotoxicology, 2010, In Press.

Sharma, A.N, K.M. Elased, J.B. Lucot. Brain region-specific alterations in monoamine processing in db/db mice. In preparation for Physiology and Behavior, 2010.

Oswal, D.P., M. Morris, J.B. Lucot. Effect of low-dose sarin exposure on the neurochemistroy of different brain structures in mice. In preparation, 2010.

Joshi, K., C.R. Rapp, T.L. Garrett, M. Davidson, D.R. Cool, J.J. Schlager, and J.B. Lucot. The effect of 8-OH-DPAT on neurodegeneration after sarin exposure. Submitted to Neurotoxicology.

Education History

Biology/Psychology, B.S. (1973), University of Pittsburgh, Pittsburgh, PA

Neurobiology, Ph.D. (1977), University of North Carolina, Chapel Hill, NC

Pharmacology and Toxicology, Postdoctoral (1977-1980), University of Chicago, Chicago, IL

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