Jeffrey Bryant Travers, M.D., Ph.D.

Department:
Pharmacology & Toxicology-SOM
Title:
Professor and Chair, Pharmacology & Toxicology Professor, Dermatology
Address:
Health Sciences Bldg 207, 3640 Colonel Glenn Hwy, Dayton, OH 45435-0001

Research Interests

I have the good fortune to be both a pharmacologist and a practicing dermatologist.  In addition to serving as Professor and Chair of the Department of Pharmacology & Toxicology, I am Professor of Dermatology and also hold a part-time 5/8th Staff Physician at the Dayton VA.  I see dermatology patients in both the WSU Department of Dermatology as well as at the Dayton VA Medical Center. 

Please see following link for updated manuscripts by Dr. Travers:

https://www.ncbi.nlm.nih.gov/pubmed?term=Travers%2C%20Jeffrey%20B%5BAuthor%5D

 

There are two major research interests of my laboratory.  First is the the pharmacology the lipid mediator Platelet-activating Factor (PAF).  We have demonstrated that PAF and related oxidized glycerophosphocholines (Ox-GPCs) are produced in response to numerous pro-oxidative environmental stimuli from UV radiation to chemotherapy and cigarette smoke exposure.  PAF-receptor agonists exert acute pro-inflammatory and delayed immunosuppressive effects.  Our models range from cultured cells to mice to humans.  These studies are supported by NIH R01 HL062996, and VA Merit 510BX000853.

Below find several recent manuscripts in this area:

125.  Abhilasha KV, Sumanth MS, Chaithra VH, Jacob SP, Thyagarajan A, Sahu RP, Rajaiah R, Prabhu KS, Kemparaju K, Travers JB, Chen CH, Marathe GK.  p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice.  Free Radic Biol Med. 143:275-287, 2019. PMID:  31442556.

123.  Yu H, Dilbaz S, Coßmann J, Hoang AC, Diedrich V, Herwig A, Harauma A, Hoshi Y, Moriguchi T, Landgraf K, Körner A, Lucas C, Brodesser S, Balogh L, Thuróczy J, Karemore G, Kuefner MS, Park EA, Rapp C, Travers JB, Röszer T.  Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages.  J. Clin. Invest. 130:2485-2499, 2019.  PMID: 31081799.

120.  Travers JB, Weyerbacher J, Ocana JA, Borchers C, Rapp CM, Sahu RP.  Acute ethanol exposure augments low dose UVB-mediated systemic immunosuppression via enhanced production of Platelet-activating factor receptor agonists.  J. Invest. Dermatol.  139(7) 1619-1622, 2019.  PMID: 30682347.

116.  Harrison KA, Romer E, Weyerbacher J, Ocana JA, Sahu RP, Murphy RC, Kelly LE, Smith TA, Rapp CM, Borchers C, Cool DR, Li G, Simman R, Travers JB.  Enhanced Platelet-activating Factor synthesis facilitates acute and delayed effects of ethanol intoxicated thermal burn injury.  J. Invest. Dermatol.  138(11):2461-2469, 2018.  PMID: 29857067.

 

Recent review:  Travers, J.B.  Platelet-activating Factor as an Effector for Environmental Stressors.  In: Lipid Signaling in Human Diseases.  Handbook of Experimental Pharmacology, eds. Cambronero, JG and Frohman M.  2019 in press.  PMID: 31087194.

The second research area is to define the role of dermal fibroblast senescence in abnormal UVB responses associated with geriatric skin.  In a long term collaborative study with Dr. Dan Spandau at Indiana University, we have defined that geriatric skin responds to UVB differently than young skin, due to differences in IGF-1 levels produced by dermal fibroblasts.  Moreover, we have found that wounding the skin via dermabrasion or fractionated laser resurfacing can result in increased dermal IGF-1 levels and normalization of the abnormal pro-carincinogenic UV response associated with geriatric skin.  We see this as a potential preventative treatment for non-melanoma skin cancer.  Moreover, we have ongoing collaborations with Dr. Ulas Sunar (WSU Engineering) using non-invasive mesocopic imaging to quantify photodamage in human subjects.  These studies are supported by NIH R01 AG048946, and VA Merit 1101CX000809.  

Below find several recent manuscripts in this area:

127.  Chen R, Wargo JJ, Williams A, Cates E, Spandau DF, Knisely C, Travers JB.  Single ablative fractional resurfacing laser treatment for forearm actinic keratoses: six month follow-up data from an intrapatient comparison between treated and untreated sites. Lasers Surg Med in press, 2019. PMID: 31736123.

 

126.  Travers JB, Kemp MG, Weir NM, Cates E, Alkawar AM, Mahajan AS, Spandau DF.  Wounding with a microneedling device corrects the inappropriate ultraviolet B radiation response in geriatric skin.  Arch Derm Res 312:1-4, 2020.  PMID: 31659432.

 

124.  Travers JB, Poon C, Bihl T, Borchers C, Rohrbach DJ, Borchers S, Trevino J, Rubin M, Donnelly H, Kellawan K, Carpenter, L, Bahl S, Rohan C, Muennich E, Guenthner S, Hahn H, Rkein A, Darst M, Mousdicas N, Cates E, Sunar U.   Quantifying skin photodamage with spatial frequency domain imaging: Statistical results.  Biomed. Optics Express.  10(9): 4676-4683, 2019.  PMID:  31565518.

 

In addition to these research interests, I have clinical expertise in inflammatory skin diseases, in particular atopic dermatitis and psoriasis.  I direct the Wright State Pharmacology Translational Unit (PTU) which conducts translational research studies and pharmacetical-funded clinical trials.  Please see the PTU website

http://wrightstatephysicians.org/ptu/ for more details

EDUCATION-TRAINING

B.S. The Ohio State University, Columbus, Ohio 1984 

Ph.D. Pharmacology, The Ohio State University, Columbus, Ohio 1990

M.D., The Ohio State University, Columbus, Ohio 1991

Transitional Internship-Riverside Methodist, Columbus Ohio 1991-92

Residency, Dermatology, University of Colorado, Denver 1992-95

Fellowship, University of Colorado and National Jewish, Denver, Colorado (with Prof. Robert Murphy) 1993-95

 

OTHER Memberships/honors

American Society for Biochemistry and Molecular Biology            

Alpha Omega Alpha Medical Honor Society

American Society for Clinical Investigation (ASCI) 

American Academy of Dermatology 

American Dermatology Association

External Advisor, Atopic Dermatitis Research Network Consortium

External Advisor, Christian Doppler Laboratory on Biotechnology of Skin Aging, Vienna Austria

International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature, PAF-Receptor (Member 2012-)

Wapakoneta Ohio High School Alumni Hall of Fame (#23)

 

 

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