
Khalid Elased, Pharm.D., Ph.D.
Research Interests
Mechanisms of Disease-Diabetes and Chronic Kidney Disease.
My current research interests focus on:
1- Understanding and manipulating the Renin-Angiotensin System (RAS) relevant to hypertension and diabetes.
2- Use of MALDI- TOF-MS and SELDI-TOF-MS to develop and optimize miniaturized novel assays for quantitative evaluation of localized and circulating RAS.
2- Our recent work focused on the development of urinary Angiotensin Converting Enzyme (ACE2 ) and neprilysin (NEP) as biomarkers for early detection of Chronic Kidney Disease in diabetic patients.
Our laboratory uses radiotelemetry, confocal microscopy, western blot and enzyme assay to investigate the effect of hyperglycemia on blood pressure, renal RAS and progression of CKD in murine model of diabetes and hypertension.
Previous research interests were focused on extraction, purification and characterization of insulin mimetic molecules from Plasmodium yoelii. These molecules are related to Glycosylphosphatiylinositos (GPIs) which could have a potential as new antidiabetic agents.
Research is funded by NHLBI, American Heart Association, WSU Boonshoft School of Medicine.
Patents:
1. Treatment of diabetes:
British Patent Application No. 9618290.2
Inventor: Elased KM, De Souza JB & Playfair JHL
Patent Number: WO98/09637, March, 1998, Patent Number: US 6,214,357, April 2001
2. Phosphoglycan messengers and their medical uses (lipidemia).
Inventors: Elased KM, Gumaa KA, De Souza JB, Rahmoune, H & Rademacher TW
British Patent Application No. 0015627.3. Filed on 26th June 2000
Published in Patents & Designs Journal (16 August 2000 No. 5805: 3559)
3. Phosphoglycan messengers and their medical uses (SLE).
Inventors: Elased KM, Gumaa KA, De Souza JB, Rahmoune H & Rademacher TW
British Patent Application No. 0012563.2. Filed on 26th June 2000
Published in Patents & Designs Journal (16 August 2000 No. 5805: 3559).
4. Screening Assay for Enzymes Involved in Patho-physiology Using SELDI-TOF Mass Spectrometry
Inventors: Elased KM & Morris M.
Attorney Docket No. WRU 0269 PA/40878.369,
US Patent Application Serial No: 11/292,806. Filed on December 2, 2005
5. Screening Assay for Inhibitors of Severe Acute Respiratory Syndrome (SARS) Using SELDI-TOF Mass Spectrometry. Inventors: Elased KM & Morris M
US Patent Application Serial No: 11/433,050. Filed on May 12, 2006
Patent granted on February 2008 (US Patent no. 7,332,296)
Education History
Doctorate of Pharmacy (Pharm.D.)
Ohio Northern University, School of Pharmacy, Ada, Ohio, USA.
Doctorate of Pharmacology (Ph.D.)
University of Strathclyde, School of Pharmacy, Glasgow, Scotland, UK.
Thesis: Stress-induced hyperinsulinemia.
Advisor: Professor Brian Furman.
Master of Science in Physiology & Pharmacology (MSc)
University of Bradford, School of Pharmacy, England, UK.
Thesis: Role of myofibroblasts in wound healing.Advisor: Professor Ian Naylor.
Bachelor of Pharmacy (B.Pharm.)
University of Khartoum, School of Pharmacy, SudanUniversity of Khartoum, School of Pharmacy, Sudan
Publications
Loretelli C, Rocchio F, D'Addio F, Ben Nasr M, Castillo-Leon E, Dellepiane S, Vergani A, Abdelsalam A, Assi E, Maestroni A, Usuelli V, Bassi R, Pastore I, Yang J, El Essawy B, Elased KM, Fadini GP, Ippolito E, Seelam AJ, Pezzolesi M, Corradi D, Zuccotti GV, Gallieni M, Allegretti M, Niewczas MA, Fiorina P. Metabolism. 2021 Aug;121:154804. doi: 10.1016/j.metabol.2021.154804. Epub 2021 Jun 10.PMID: 34097917
Alawi LF, Dhakal S, Emberesh SE, Sawant H, Hosawi A, Thanekar U, Grobe N, Elased KM. Front Pharmacol. 2021 Jan 29;11:602985. doi: 10.3389/fphar.2020.602985. eCollection 2020.PMID: 33708117
Alawi LF, Emberesh SE, Owuor BA, Chodavarapu H, Fadnavis R, El-Amouri SS, Elased KM. Physiol Rep. 2020 Feb;8(3):e14364. doi: 10.14814/phy2.14364.PMID: 32026607.
Yermakov LM, Drouet DE, Griggs RB, Elased KM, Susuki K. Front Cell Neurosci. 2018 Jun 8;12:146. doi: 10.3389/fncel.2018.00146. eCollection 2018.PMID: 29937715.
Gutta S, Grobe N, Kumbaji M, Osman H, Saklayen M, Li G, Elased KM. Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F263-F274. doi: 10.1152/ajprenal.00565.2017. Epub 2018 Mar 21.PMID: 29561187.
Grobe N, Elased KM. Methods Mol Biol. 2017;1614:189-197. doi: 10.1007/978-1-4939-7030-8_15.PMID: 28500605
Domenig O, Manzel A, Grobe N, Königshausen E, Kaltenecker CC, Kovarik JJ, Stegbauer J, Gurley SB, van Oyen D, Antlanger M, Bader M, Motta-Santos D, Santos RA, Elased KM, Säemann MD, Linker RA, Poglitsch M. Sci Rep. 2016 Sep 21;6:33678. doi: 10.1038/srep33678.PMID: 27649628.
Otaño-Rivera V, Boakye A, Grobe N, Almutairi MM, Kursan S, Mattis LK, Castrop H, Gurley SB, Elased KM, Boivin GP, Di Fulvio M. Lab Anim. 2017 Apr;51(2):138-146. doi: 10.1177/0023677216646088. Epub 2016 Jul 10.PMID: 27166392.
Grobe N, Di Fulvio M, Kashkari N, Chodavarapu H, Somineni HK, Singh R, Elased KM. Am J Physiol Cell Physiol. 2015 May 1;308(9):C767-77. doi: 10.1152/ajpcell.00247.2014. Epub 2015 Mar 4.PMID: 25740155.
Grobe N, Leiva O, Morris M, Elased KM. PLoS One. 2015 Feb 23;10(2):e0117899. doi: 10.1371/journal.pone.0117899. eCollection 2015.PMID: 25706121.
Boivin GP, Elenes EY, Schultze AK, Chodavarapu H, Hunter SA, Elased KM. Muscles Ligaments Tendons J. 2014 Nov 17;4(3):280-4. eCollection 2014 Jul. PMID: 25489543.
Sharma AN, Ligade SS, Sharma JN, Shukla P, Elased KM, Lucot JB. Metab Brain Dis. 2015 Apr;30(2):519-27. doi: 10.1007/s11011-014-9591-7. Epub 2014 Jul 15.PMID: 25023888
Somineni HK, Boivin GP, Elased KM.J Endocrinol. 2014 Apr 22;221(2):235-51. doi: 10.1530/JOE-13-0532. Print 2014 May. PMID: 24756098.
Alghamri MS, Morris M, Meszaros JG, Elased KM, Grobe N. Am J Physiol Heart Circ Physiol. 2014 Apr 1;306(7):H1032-40. doi: 10.1152/ajpheart.00911.2013. Epub 2014 Jan 24.PMID: 24464749.
Salem ES, Grobe N, Elased KM. Am J Physiol Renal Physiol. 2014 Mar 15;306(6):F629-39. doi: 10.1152/ajprenal.00516.2013. Epub 2014 Jan 22.PMID: 24452639.
Ernst A, Sharma AN, Elased KM, Guest PC, Rahmoune H, Bahn S. Transl Psychiatry. 2013 May 28;3(5):e263. doi: 10.1038/tp.2013.42.PMID: 23715298.
Chodavarapu H, Grobe N, Somineni HK, Salem ES, Madhu M, Elased KM. PLoS One. 2013 Apr 30;8(4):e62833. doi: 10.1371/journal.pone.0062833. Print 2013.PMID: 23646149.
Dixit TS, Sharma AN, Lucot JB, Elased KM. Physiol Behav. 2013 Apr 10;114-115:38-41. doi: 10.1016/j.physbeh.2013.03.008. Epub 2013 Mar 21.PMID: 23523479
Grobe N, Weir NM, Leiva O, Ong FS, Bernstein KE, Schmaier AH, Morris M, Elased KM. Am J Physiol Cell Physiol. 2013 May 15;304(10):C945-53. doi: 10.1152/ajpcell.00346.2012. Epub 2013 Feb 7.PMID: 23392115.
Alghamri MS, Weir NM, Anstadt MP, Elased KM, Gurley SB, Morris M.J Cardiovasc Pharmacol Ther. 2013 Mar;18(2):138-51. doi: 10.1177/1074248412460124. Epub 2012 Oct 5.PMID: 23043153
Senador D, Shewale S, Irigoyen MC, Elased KM, Morris M. Exp Diabetes Res. 2012;2012:459087. doi: 10.1155/2012/459087. Epub 2012 Mar 29.PMID: 22536215.
- Rosiglitazone treatment reversed depression- but not psychosis-like behavior of db/db diabetic mice.
Sharma AN, Elased KM, Lucot JB. J Psychopharmacol. 2012 May;26(5):724-32. doi: 10.1177/0269881111434620. Epub 2012 Feb 12.PMID: 22331176
Grobe N, Elased KM, Cool DR, Morris M. Am J Physiol Endocrinol Metab. 2012 Apr 15;302(8):E1016-24. doi: 10.1152/ajpendo.00515.2011. Epub 2012 Feb 7.PMID: 22318946.
Agbor LN, Elased KM, Walker MK. Biochem Pharmacol. 2011 Sep 1;82(5):514-23. doi: 10.1016/j.bcp.2011.06.011. Epub 2011 Jun 13.PMID: 21684261.
Sharma AN, Elased KM, Garrett TL, Lucot JB. Physiol Behav. 2010 Oct 5;101(3):381-8. doi: 10.1016/j.physbeh.2010.07.002. Epub 2010 Jul 14.PMID: 20637218.
Kopf PG, Scott JA, Agbor LN, Boberg JR, Elased KM, Huwe JK, Walker MK. Toxicol Sci. 2010 Oct;117(2):537-46. doi: 10.1093/toxsci/kfq218. Epub 2010 Jul 15.PMID: 20634294.
Zhang N, Agbor LN, Scott JA, Zalobowski T, Elased KM, Trujillo A, Duke MS, Wolf V, Walsh MT, Born JL, Felton LA, Wang J, Wang W, Kanagy NL, Walker MK. Biochem Pharmacol. 2010 Jul 15;80(2):197-204. doi: 10.1016/j.bcp.2010.03.023. Epub 2010 Mar 30.PMID: 20359465.
Senador D, Key M, Brosnihan KB, Irigoyen MC, Elased KM, Morris M.J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):68-77. doi: 10.1177/1074248409351409. Epub 2009 Dec 7.PMID: 19995939.
Senador D, Kanakamedala K, Irigoyen MC, Morris M, Elased KM. Exp Physiol. 2009 Jun;94(6):648-58. doi: 10.1113/expphysiol.2008.046474. Epub 2009 Feb 13.PMID: 19218356.
Elased KM, Cunha TS, Marcondes FK, Morris M. Exp Physiol. 2008 May;93(5):665-75. doi: 10.1113/expphysiol.2007.040311. Epub 2008 Feb 8.PMID: 18263657.
Farah V, Elased KM, Morris M. Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H1083-9. doi: 10.1152/ajpheart.00106.2006. Epub 2007 Apr 20.PMID: 17449556
Cunha TS, Farah V, Paulini J, Pazzine M, Elased KM, Marcondes FK, Cláudia Irigoyen M, De Angelis K, Mirkin LD, Morris M. Regul Pept. 2007 Mar 1;139(1-3):1-4. doi: 10.1016/j.regpep.2006.11.023. Epub 2007 Jan 4.PMID: 17207869
Farah V, Elased KM, Chen Y, Key MP, Cunha TS, Irigoyen MC, Morris M. Auton Neurosci. 2006 Dec 30;130(1-2):41-50. doi: 10.1016/j.autneu.2006.05.006. Epub 2006 Jul 13.PMID: 16843071
Elased KM, Cunha TS, Gurley SB, Coffman TM, Morris M. Hypertension. 2006 May;47(5):1010-7. doi: 10.1161/01.HYP.0000215588.38536.30. Epub 2006 Apr 3.PMID: 16585421
Elased KM, Cool DR, Morris M. Hypertension. 2005 Oct;46(4):953-9. doi: 10.1161/01.HYP.0000174601.30793.b1. Epub 2005 Aug 15.PMID: 16103259
Elased KM, Gumaa KA, de Souza JB, Playfair JH, Rademacher TW. Metabolism. 2004 Aug;53(8):1048-53. doi: 10.1016/j.metabol.2004.03.013.PMID: 15281017
Elased KM, Gumaa KA, de Souza JB, Rahmoune H, Playfair JH, Rademacher TW. Mol Genet Metab. 2001 Jul;73(3):248-58. doi: 10.1006/mgme.2001.3186.PMID: 11461192
Elased KM, de Souza JB, Playfair JH. Metabolism. 2000 Jul;49(7):937-41. doi: 10.1053/meta.2000.6756.PMID: 10910007
Elased KM, Taverne J, Playfair JH. Clin Exp Immunol. 1996 Sep;105(3):443-9. doi: 10.1046/j.1365-2249.1996.d01-781.x.PMID: 8809132.
Taverne J, Sheikh N, Elased K, Playfair J, Scott M, Saggerson D. Parasitol Today. 1996 Jul;12(7):290. doi: 10.1016/0169-4758(96)80817-9.PMID: 15275196 No abstract available.
Elased KM, Playfair JH. Parasitology. 1996 Jun;112 ( Pt 6):515-21. doi: 10.1017/s0031182000066087.PMID: 8684825
Taverne J, Sheikh N, Elased K, Playfair J. Parasitol Today. 1995 Dec;11(12):462-3; author reply 463. doi: 10.1016/0169-4758(95)80060-3.PMID: 15275384 No abstract available.
Elased K, De Souza JB, Playfair JH. Clin Exp Immunol. 1995 Mar;99(3):440-4. doi: 10.1111/j.1365-2249.1995.tb05570.x.PMID: 7882567.
Elased K, Playfair JH. Infect Immun. 1994 Nov;62(11):5157-60. doi: 10.1128/iai.62.11.5157-5160.1994.PMID: 7927799.
Elased KM, Furman BL. Metabolism. 1994 Oct;43(10):1221-5. doi: 10.1016/0026-0495(94)90214-3.PMID: 7934972
Professional Affiliations/Memberships
PROFESSIONAL SOCIETY MEMBERSHIP:
2014- Present: Member of the American Society of Physiology (ASP).
2013- Present: Member of the American Society of Nephrology (ASN).
2011- Present: Member of the American College of Clinical Pharmacy (ACCP).
2010- Present: Delegate of Boonshoft School of Medicine to the United States Pharmacopeia (USP) Conventions.
2008- Elected Fellow in the American Heart Association (AHA) Council of High Blood Pressure.
2005- 2009: Member of the American Society for Pharmacology and Experimental Therapeutics (ASPET).
2004- Present: Member of the American Heart Association (AHA).
1999- Present: Member of the American Diabetic Association (ADA).
1990- Present: Member of the European Association for the Study of Diabetes (EASD).