Kuppuswamy Arumugam, Ph.D.

Department:
Chemistry
Title:
Associate Professor
Address:
Oelman Hall 408, 3640 Colonel Glenn Hwy, Dayton, OH 45435-0001

Biography

Swamy received his Ph.D from Tulane University, New Orleans, LA, followed with a postdoctoral stint at The University of Texas at Austin. Before moving to Wright State he worked at St. Bonaventure University as an Assistant Professor. His research interests lie in the interface between organometallic chemistry, catalysis, material sciences and biology. In his free time, he enjoys spending time with his family, biking, running, hiking, and being outdoors.

Education History

Master of Science – Pondicherry University

Doctorate of Philosophy in Chemistry – Tulane University

Post Doctoral Research Associate – Department of Chemistry, The University of Texas Austin

Current Reserch Interests/Projects

Our research interests lie in the interface between organometallic chemistry, materials sciences, and biology. Our studies involve the synthesis of several organometallic complexes/polymers that posses interesting catalytic, photophysical and anti-cancer properties.

1) An Electrochemical Approach to Control the Ring size of Cyclic Polyester

Cyclic polyesters have attracted attention as potential drug delivery vectors; however, in order to be viable for biomedical applications, cyclic polyesters with low PDIs and enhanced molecular weight control are necessary. The zwitterionic polymerizations for preparation of cyclic polyesters using N-heterocyclic carbenes (NHCs) are promising; they deliver a higher degree of control over molecular weight distributions. However, the key concerns requiring attention are the mode of catalyst introduction and recovery, controlled reactivity, and the inability to achieve precision molecular architecture. Based on a new principle, an integrated electrochemical approach coupled with zwitterionic polymerizations will be used to address the above mentioned issues.

2) Cytotoxicity of Redox Active N-Heterocyclic Carbene Annulated Gold Complexes

Several (NHC)AuCl complexes have been reported for anticancer activity. They exploit either metal-based reactivity with the selenoenzyme Thioredoxin Reductase (TrxR) and/or mitochondrial swelling induced by their delocalized lipophilic cation (DLC) behavior to show anticancer effects. In certain cases, these complexes have proven to be more cytotoxic than cisplatin in a human urothelial cancer cell line, a prostate carcinoma cell line, and a breast carcinoma cell line. We investigate the intrinsic antineoplastic properties of redox active ligands with the known anticancer effects of NHC-gold complexes.

3) Functional Polymeric Hybrid Materials

Macromolecules containing metal centers are emerging as an interesting class of molecules that are targeted for potential applications such as emissive materials. The key to developing such metallopolymers hinges on the development of new tunable molecular scaffolds (linkers) that can bridge a variety of transition metals. A modular approach for synthesis of tunable molecular scaffolds incorporating NHC-dithiolene functionalities will be investigated. 

Contact:

Department of Chemistry, 408 Oelman Hall

Wright State University

3640 Colonel Glenn Hwy., Dayton, OH, 45435

kuppuswamy.arumugam@wright.edu

T:937-775-4661; F:937-775-2717

 

Selected Publications:

•  Targeting Antioxidant Pathways with Ferrocenylated N-Heterocyclic Carbene Supported Gold(I) Complexes in A549 Cancer Cells Arambula, J. F,* MCCall, R., Sidoran, K., Magda, D., Mitchell, N., Bielawski, C., Lynch, V., Sessler, J. and Arumugam, K.* Chem. Sci., 2015 (In Press). 

•   Redox Switchable Ring-Closing Metathesis: Catalyst Design, Synthesis and Study. Arumugam, K.; Varnado, D. C.; Sproules, S.; Lynch, V. M.; Bielawski, C. W. Chem. Eur. J.2013, 19, 10866. 

•   Cationic Ir Complexes Containing Anionic Ir Counterions Supported by Redox-Active N-Heterocyclic Carbenes. Arumugam, K.; Chang. J.; Lynch, V. M.; Bielawski, C. W. Organometallics2013, 32, 4334. 

•   Long Range Spin Coupling: A Tetraphosphine-Bridged Palladium Dimer. Arumugam. K.; Mohamed, C. S.; Mague, J. T.; Bill, E.; Sproules, S.; Donahue, J. P. Inorg. Chem. 201150, 2995–3002. 

•   Synthesis and Properties of 1,2,4,5-Benzenetetrathiolate-Linked Group(VII) Metal Complexes. Arumugam. K.; Mohamed, C. S.; Perumalreddy, C.; Villgrán, D.; Gray, T. G.; Mague, J. T.; Donahue, J. P. Inorg. Chem.200948, 10591–10607. 

•   Synthesis, Structures and Properties of Mixed Dithiolene-Carbonyl and Dithiolene-Phosphine Complexes of Tungsten. Perumalreddy, C.; Arumugam, K.; Upul, J.; Lisa, M. P.; Joel, T. M.; Donahue, J. P. Inorg. Chem.200948, 2103–2113. 

•   A Convergent Approach to the Synthesis of Multimetallic Dithiolene Complexes. Arumugam, K.; Yu, R.; Villgrán, D.; Gray, T. G.; Mague, J. T.; Donahue, J. P. Inorg. Chem.200847, 5570–5572. 

•   Reversible, Electrochemically Controlled Binding of Phosphine to Iron and Cobalt Bis(dithiolene) Complexes. Yu, R.; Arumugam, K.; Manepalli, A.; Tran, Y.; Schmehl, R.; Jacobsen, H.; Donahue, J. P. Inorg. Chem.200746, 5131–5133. 

•   Preparation and Isolation of Dithiolene Thiophosphoryl Molecules as Stable, Protected Forms of Dithiolene Ligands. Arumugam, K.; Bollinger, J.; Fink, M.; Donahue, J. P. Inorg. Chem.200746, 3283–3288. 

 

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