Michael P. Markey, PhD

Biochemistry/Molecular Biology-SOM
Research Associate Professor, Biochemistry & Molecular Biology; Director, Center for Genomics Research
Diggs Laboratory 048, 3640 Colonel Glenn Hwy., Dayton, OH 45435-0001

Education History

Doctoral: University of Cincinnati (Erik S. Knudsen)
Postdoctoral: Wood Hudson Cancer Research Laboratory (Taiping Chen)
Postdoctoral: Wright State University (Steven J. Berberich)


2011-present BMB 8990 Graduate Research
2022    BMB 7600 Molecular Biology of the Nucleus
2022    Foundations of Clinical Practice: Balance, Control, and Repair
2021    Clinical Medicine Doctoring
2021    BMB 3850 Biochemistry Laboratory
2021    BMB 4020/6020 Research Perspectives
2021    BMB 7660 Systems Biology
2021    Foundations of Clinical Practice: Beginning to End
2021    Foundations of Clinical Practice: Origins II
2021    BMB 4750 Molecular Biology of Cancer
2020    BMB/BMS 7600 Molecular Biology of the Nucleus
2020    Foundations of Clinical Practice: Balance, Control, and Repair
2020    Foundations of Clinical Practice: Beginning to End
2020    BMB 3850 Biochemistry Laboratory
2020    BMB 4870 Undergraduate Research

2020       BSoM Origins II
2020       BSoM Balance Control and Repair
2020       BMB 3850 Undergraduate Lab
2019       BMB 7660 Systems Biology
2019       BMB 4020/6020 Research Perspectives
2019       BMB 4700 Molecular Biology of RNA
2019       BMB 4750 Molecular Biology of Cancer
2019       BMB 3850 Undergraduate Lab
2019       BSoM Origins II
2019       BSoM Medical Journal Club
2018       BSoM Staying Alive
2018       BSoM Origins II
2017       BSoM Origins I
2017       BSoM Origins II
2017       BSoM Pathobiology and Therapeutics
2017       BMB 3850 Biochemistry Lab
2016       BSoM Pathobiology and Therapeutics
2014       BMB/BMS 7650 Computational Tools and Strategies
2014       BMB/BMS 7670 Molecular Basis of Inherited Disease
2013       BMB/BMS 7600 Molecular Biology of the Nucleus
2013       BMB 4990 Undergraduate Research
2012       BMB/BMS 991 Molecular Basis of Inherited Disease
2012       BMS-996 Laboratory Rotation
2012       BMB-760 / BMS-760 Molecular Biology of the Nucleus
2011       BMB-753/BMS-753 Molecular Signaling
2009       BMB-760/BMS-760 Molecular Biology of the Nucleus
2009       BMB 499 Undergraduate Research
2008       BMB 703 Research Ethics
2007       BMB 703 Research Ethics
2007       BMB-765, Computational Tools and Strategies
2007       BMB-760/BMS-760 Molecular Biology of the Nucleus
2005       20 BME 643 Introduction to Bioinfomatics (University of Cincinnati)
2000       BIO 597 Special Topics in Molecular Biology (Murray State University)

Research Statement

As Director of the Center for Genomics Research (CGR), I facilitate the projects of other researchers at WSU as well as external investigators who wish to collaborate or contract with the CGR. These projects have included topics in neuroscience, toxicology, and molecular biology. Current projects include the genetics of motion sickness, the body's response to physical training, epigenetic modification of RNA, alternative splicing in melanoma, and single-cell quantification of gene expression in neurons. Please contact CGR if you are interested in collaborative work involving any topics in genomics.


Grant Reviewer:              
NIH Provocative Questions Study Section (2018)
Grantové agentura České republiky (Czech Science Foundation) (2011, 2021)

Journal Reviewer:           
Cancers (2021)
International Journal of Biological Sciences (2021)
Cytogenetic and Genome Research (2020)
International Journal of Molecular Science (2020)
Materials (2020)
Gene (2020)
Gene (2019)
Cellular Physiology and Biochemistry (2018)
Current Cancer Drug Targets (2018)
Genes (2017)
Cellular Physiology and Biochemistry (2016)
Oncotarget (2016)
PLoS ONE (2016)
African Journal of Biotechnology (2015, 2016)
Cancer Biomarkers (2014)
Oncotargets and Therapy (2013)
Carcinogenesis (2013)
FEBS Journal (2013)
Journal of Cell Biology (2013)
Apoptosis Reviews (2011)
Cell Cycle (2011)
Physiological Genomics (2011)

BMS Admissions Committee (2020-2022)
BMS Nominating Committee (2019-2020, Chair)
WSU Graduate Council, BSOM faculty representative (2014-2018)
BMS Admissions Committee (2014-2015, Chair 2016)
Dayton Biorepository Steering Committee (2014-2016)
Boonshoft School of Medicine Graduate Council Membership subcommittee (2014-2018)
College of Science and Mathematics Program Review Committee (2014-2015)
BMB Graduate Education Committee (GEC) (2014)
BMB MS Program Student Assessment Committee, Chair (2013)
BMS Nominating Committee (2013)
BMS Nominating Committee, chair (2014)
Celebration of Research, Scholarship, and Creative Activities, Chair, Session 4 (2012)
BSOM Research Affairs Committee (2010-2013)
Wright State University & Premier Health Partners Neuroscience Institute Steering Committee (2010)
Comprehensive Neuroscience Steering Committee (2008-2010)

Judge, Intel® International Science and Engineering Fair (ISEF), Montgomery County Science and Engineering Fair (2011-2019)          
Participant, Take Our Sons and Daughters to Work Day (2016-2018)
American Cancer Society Lab Tour Event (2015)
The Hour of Code, Lebanon Public Library (2015)
“The Complete Evidence for Evolution, Abridged”, Harmony UU Church, Mason, OH (2014)
Judge, St. Peter Catholic School science fair, Huber Heights, OH (2008, 2011)
Judge, 3rd Annual Greene County Science and Engineering Day (2008)

Co-founded Molecular Oncology Diagnostics, LLC (2013-2017)

Students Advised

Thesis advisor for:
2018-2020            Abdullah Alatawi(MS)
2017-2019            Stacy Simmons (MS)
2015-2017            Minyi Chen (MS)
2013-2015            Ahmed Mahas (MS)
2013-2015            Keerti Potluri (MS)
2010-2012            Sameep Naik (MS)
2010-2012            Pooja Mandke (MS)
Thesis committee member for:
2021-2025    Restha Shrestha (PhD)
2021-2022    Monica Christian (MS)
2020-2021    Nicole Waters (MS)
2019-2022    Clayton Alex-Bruckner (PhD)
2019-2021    Andrew Browder (MS)
2019-2021    French Damewood (MS)
2019-2020    Sandhya Sattiraju (MS)
2018-2022    William Cvammen Ph.D.
2018-2022    John Miller (PhD)
2018-2022    Venicia Hawach (PhD)
2018-2022    Akshay Hira (PhD)
2018-2021    SoonJye Kho (PhD)
2017-2021    Andrew Stacy (PhD)
2017-2021    Alex Gordon (PhD)
2017-2020    Prithy Martis (PhD)
2017-2020    Langni Liu (PhD)
2019-2020            Tushar Goswami (MS)
2017-2021            Andrew Stacy (PhD)
2017-2021            Alex Gordon (PhD)
2017-2019            John Trombley (MS)
2016-2018            Sarah Kovar (MS)
2015-2018            Hima Yalamanchili (PhD)
2015-2017            Hadel Alsaran (MS)
2015-2017            Abdullah Alshudukhi (MS)
2015-2017            Andrew Stacy (MS)
2016-2020            Alex Gordon (PhD)
2016-2017            Abdullah Alshudukhi (MS)
2016-2017            Caitlan Castagno (MS)
2016-2017            Rujuta Yashodhan (MS)
2015-2016            Andrea Klingler (MS)
2015-2016            Hadel Alsaran (MS)
2015-2016            Ramya Ganesan (MS)
2015-2016            Amal Albati (MS)
2014-2015            Nouf Alharbi (MS)
2012                       Erin Nass-Welbaum (MS)
2012                       Joseph Rotsinger (MS)
2011                       Laura Rigsbee (MS)
2008                       Vaughn Litteral (MS)
2008                       Harshavardhan Kenche (MS)
2008                       Casey Wells (MS)

Undergraduate research advisor for:
2018-2020              Karleigh Kessler
2012                       Amy Kerry
2012                       Sue Culbertson
2008-2010             Jillian Fraser
2008-2010             Nicholas Wyatt
2008-2010             Benjamin Bates

High school research advisor for:
2012-2013            Townsend Smith, IV

Other Instructional Activities
2012-2013            National Institute of Diabetes and Digestive and Kidney Diseases Short-Term Education Program for Underrepresented Persons (STEP-UP) program
2010-2013            Frontiers in Translational Medicine, Translational Biomedical Training for Underrepresented Minorities (STREAMS) program
2010                     Wright Scholars (high school STEM mentor program)


  1. Alatawi A., Kho S., Markey M. “MDM4 isoform expression in melanoma supports an oncogenic role for MDM4-A”. Submitted to the Journal of Skin Cancer. May 26, 2021.
  2. Turner A, Markey M, Le P, Reiter A, Cox C, Simmons S, Rao MB, Altman L, Davis K, Huber D, Dufour JS, Marras W, Bhattacharya A. “Disorientation Effects, Circulating Small RNA, and Genetic Susceptibility on Static Postural Stability”. Submitted to Clinical Biomechanics. 2021, February 5.
  3. Spandau DF, Chen R, Wargo J, Rohan C, Southern D, Zhang A, Loesch M, Weyerbacher J, Tholpady S, Lewis D, Kuhar MJ, Tsai KY, Kemp MG, Markey M, Cates E, Williams A, Knisely C, Bashir S, Gabbard R, Hoopes R, Travers JB. “Evidence that cutaneous wounding can prevent non-melanoma skin cancer in aged skin: results from a randomized, prospective, controlled trial". In press at the Journal of Clinical Investigation, 2021, April 29.
  4. Dufour JS, Reiter A, Cox C, Weston EB, Markey M, Turner A, Le P, Aurand AM, Simmons S, Altman L, Mageswaran P, Davis K, Huber D, Bhattacharya A, Marras WS. “Motion sickness decreases low back function and changes gene expression of military aircrew”. Submitted to Clinical Biomechanics, 2021, May 7.
  5. Chen M., Myers, AK, Markey, MP, Long, W. “The atypical MAPK ERK3 potently suppresses melanoma cell growth and invasiveness”. J Cell Physiol. 2018 Dec 19. doi: 10.1002/jcp.27994. PMID: 30569573
  6. PK Lauf, , S Aygün-Sunar,, GK Begum, C Maharjan, MP Markey, MI Wormstone, and NC Adragna “Long-term Ouabain treatment promotes ATP1A1-dependent IL-6 expression in a fetal human lens epithelial cell line (FHL124)”. The FASEB Journal 2018 32:1_supplement, lb437-lb437
  7. Almazan EMP, Lesko SL, Markey MP, Rouhana L. “Girardia dorotocephala transcriptome sequence, assembly, and validation through characterization of piwi homologs and stem cell progeny markers”. Dev Biol. 2018 Jan 15;433(2):433-447. doi: 10.1016/j.ydbio.2017.07.022. Epub 2017 Aug 1. PMID: 28774726
  8. Varia S, Cheedu D, Markey M, Torres-Shafer K, Battini VP, Bubulya A, Bubulya PA. “Alignment of Mitotic Chromosomes in Human Cells Involves SR-Like Splicing Factors Btf and TRAP150”. Int J Mol Sci. 2017 Sep 12;18(9). pii: E1956. doi: 10.3390/ijms18091956. PMID: 28895891
  9. Havemann LM, Cool DR, Gagneux P, Markey MP, Yaklic JL, Maxwell RA, Iyer A, Lindheim SR. “Vulvodynia: What We Know and Where We Should Be Going”. J Low Genit Tract Dis. 2017 Apr;21(2):150-156. Review. PMID: 27984345.
  10. Wong P, Markey M, Rapp CM, Darrow RM, Ziesel A, Organisciak DT. “Enhancing the efficacy of AREDS antioxidants in light-induced retinal degeneration”. Mol Vis. 2017 Oct 10;23:718-739. eCollection 2017. PMID: 29062223
  11. Martis PC, Dudley A, Laramore MA, Gazda HL, et al. “Chemoresistant cancer stem cells undergo gene changes that drive tumor recurrence”. Cancer Res Vol. 77 Iss. 13 sup Apr (2017) ISSN: 0008-5472 doi:10.1158/1538-7445.AM2017-3891
  12. Mahas A, Potluri K, Kent MN, Naik S, Markey M. “Copy number variation in archival melanoma biopsies versus benign melanocytic lesions”. Cancer Biomarkers.2016 Mar 11;16(4):575-97. PMID: 27002761
  13. Potluri K, Mahas A, Kent MN, Naik S, Markey M. “Genomic DNA extraction methods using formalin-fixed paraffin-embedded tissue”. Anal Biochem. 2015 Jun 27;486:17-23. PMID: 26126956
  14. Morgan MS, Arlian LG, Markey MP. “Sarcoptes scabiei mites modulate gene expression in human skin equivalents”. PLoS One. 2013 Aug 5;8(8):e71143. PMID: 23940705
  15. Mandke P, Bates B, Wyatt N, Fraser J, Berberich SJ, and Markey MP “MicroRNA-34a Modulates MDM4 Expression via a Target Site in the Open Reading Frame”. PLoS One. 2012;7(8):e42034. PMID: 22870278
  1. Sharma, A, Markey, M, Torres-Muñoz, K, Varia, S, Kadakia, M, Bubulya, A, and Bubulya, PA. “Son Maintains Accurate Splicing for a Subset of Human Pre-mRNAs”, J Cell Sci. 2011 Dec 15;124(Pt 24):4286-98. Epub 2011 Dec 22. PMID: 22193954
  2. Markey MP.“Regulation of MDM4”.Frontiers in Bioscience 16, 1144-1156, January 1, 2011. PMID: 21196223
  3. Heminger H, Markey M, Mpagi M and Berberich SJ “Alterations in gene expression and sensitivity to genotoxic stress following HdmX knockdown in human tumor cells harboring wild-type p53”. Aging. 2009 Jan 7;1(1):89-108. PMID: 19946469
  4. Markey, M and Berberich, S. “Full-length HdmX Transcripts are Reduced Following Genotoxic Stress”.Oncogene, 2008 Nov 27;27(52):6657-66. PMID: 18711402
  5. Markey, MP, Bergseid J, Bosco EE, Stengel K, Xu H, Mayhew CN, Schwemberger SJ, Braden WA, Jiang Y, Babcock GF, Jegga AG, Aronow BJ, Reed MF, Wang JY, Knudsen ES. "Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function". Oncogene 2007 26, 6307-6318. PMID: 17452985
  6. Chen T, Jackson CR, Link A, Markey MP, Colligan BM, Douglass LE, Pemberton JO, Deddens JA, Graff JR, Carter JH. "Int7G24A variant of transforming growth factor-beta receptor type I is associated with invasive breast cancer". Clinical Cancer Research. 2006 Jan 15;12(2):392-7. PMID: 16428477
  7. Markey M, Siddiqui H, Knudsen ES. "Geminin is Targeted for Repression by the RB Pathway Through Intragenic E2F Sites". J Biol Chem. 2004 Jul 9;279(28):29255-62. PMID: 15084580
  8. Angus SP, Mayhew CN, Solomon DA, Braden WA, Markey MP, Okuno Y, Cardoso MC, Gilbert DM, Knudsen ES. "RB Reversibly Inhibits DNA Replication by Two Temporally Distinct Mechanisms". Mol Cell Biol. 2004 Jun;24(12):5404-20. PMID: 15169903
  9. Markey MP, Angus SP, Strobeck MW, Williams SL, Gunawardena RW, Aronow BJ, Knudsen ES."Unbiased Analysis of RB-Mediated Transcriptional Repression Identifies Novel Targets and Distinctions from E2F Action." Cancer Research. 2002 Nov 15; 62(22):6587-97. PMID: 12438254
  10. Angus SP, Wheeler LJ, Ranmal SA, Zhang X, Markey MP, Mathews CK, Knudsen ES. "The Retinoblastoma Tumor Suppressor Targets dNTP Metabolism To Regulate Cell Cycle Progression." J Biol Chem. 2002 Nov 15;277(46):44376-84. PMID: 12221087
  11. Angus SP, Fribourg AF, Markey MP, Williams SL, Horn HF, DeGregori J, Kowalik TF, Fukasawa K, Knudsen ES. "Active Rb Elicits Late G1/S Inhibition." Exp Cell Res. 2002 Jun 10;276(2):201-13. PMID: 12027450
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