Quan Zhong, Ph.D.

Biological Sciences
Assistant Professor
Diggs Laboratory 254, 3640 Colonel Glenn Hwy, Dayton, OH 45435-0001

          Lab webpage


Education History: 



BIO 2110                 Principles of Molecular and Classical Genetics
BIO 4020/6020      Current Literature in Network Biology


Research statement: 

Living organisms are composed of dynamically interacting molecules, collectively operating at a wide spectrum of spatial and temporal scales. We develop tools and strategies to map and analyze interaction networks of proteins, and employ such networks to study systems level coordination of diverse cellular processes and perturbation of such networks in disease. We care about biochemical details in proteins that drive their interactions, how such details have evolved, and how they govern complex biological functions.




My Bibliography

Martínez-Noël G, Luck K, Kühnle S, Desbuleux A, Szajner P, Galligan JT, Rodriguez D, Zheng L, Boyland K, Leclere F, Zhong Q, Hill DE, Vidal M, Howley PM. Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes. J Mol Biol. 2018 Mar 30;430(7):1024-1050. doi: 10.1016/j.jmb.2018.01.021. Epub 2018 Feb 6.

Jo M, Chung AY, Yachie N, Seo M, Jeon H, Nam Y, Seo Y, Kim E, Zhong Q, Vidal M, Park HC, Roth F, Suk K. Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target. Genome Res. 27:1487 (2017) doi: 10.1101/gr.211649.116.

Khurana V*, Peng J*, Chung CY*, Auluck PK, Fanning S, Tardiff DF, Bartels T, Koeva M, Eichhorn SW, Benyamini H, Lou Y, Nutter-Upham A, Baru V, Freyzon Y, Tuncbag N, Costanzo M, SanLuis BJ, Schöndorf DC, Barrasa MI, Ehsani S, Sanjana N, Zhong Q, Gasser T, Bartel DP, Vidal M, Deleidi M, Boone C, Fraenkel E, Berger B, Lindquist S.   Genome-scale networks link neurodegenerative disease genes to alpha-synuclein through specific molecular pathways. Cell Systems 4:157 (2017) *Equal contributors

Zhong Q*$, Pevzner SJ*, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Taşan M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barabási AL, Hill DE, Aloy P, Cusick ME, Xia Y$, Roth FP$, Vidal M$. An inter-species protein-protein interaction network across vast evolutionary distance. Molecular Systems Biology 12:865 (2016) *Equal contributors $Co-corresponding

Yang X*, Coulombe-Huntington J*, Kang S*, Sheynkman GM*, Hao T*, Richardson A, Sun S, Yang F, Shen Y, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M. Widespread expansion of protein interaction capabilities by alternative splicing. Cell 164:805 (2016) *Equal contributors

Sahni N*, Yi S*, Taipale M*, Fuxman Bass JI*, Coulombe-Huntington J,* Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovács IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y1, Cusick ME, Salehi-Ashtiani K8, Whitesell LJ, Sunyaev S, Berger B, Barabási AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJ, Lindquist S, Vidal M. Widespread macromolecular interaction perturbations in human genetic disorders. Cell 161:647 (2015) *Equal contributors

Rolland T*, Taşan M*, Charloteaux B*, Pevzner SJ*, Zhong Q*, Sahni N*, Yi S*, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M. A proteome-scale map of the human interactome network. Cell 159:1212 (2014) *Equal contributors

Wang W, Zhong Q, Teng L, Bhatnagar N, Sharma B, Zhang X, Luther W 2nd, Haynes LP, Burgoyne RD, Vidal M, Volchenboum S, Hill DE, George RE. Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma. Oncogene 33:3316 (2014)

Sahni N, Yi S, Zhong Q, Jailkhani N, Charloteaux B, Cusick ME and Vidal M. Edgotype: a fundamental link between genotype and phenotype. Curr Opin Genet Dev. 23:649 (2013) 

Lambert JP, Ivosev G, Gouzens AL, Larsen B, Taipale M, Lin ZY, Zhong Q, Lindquist S, Vidal M, Aebersold R, Pawson T, Bonner R, Tate S, Gingras AC. Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition.  Nat Methods 10:1239 (2013)

Ju S, Tardiff DF, Han H, Divya K, Zhong Q, Maquat LE, Bosco DA, Hayward LJ, Brown RH Jr, Lindquist S, Ringe D, Petsko GA. A yeast model of FUS/TLS-dependent cytotoxicity. J  PLoS Biol 9:e1001052 (2011)

Charloteaux B*, Zhong Q*, Dreze M*, Cusick ME, Hill DE, Vidal M. Protein-protein interaction networks: Forward and reverse edgetics. Methods Mol Biol 759:197 (2011) *Equal contributors

Zhong Q*, Simonis N*, Li QR*, Charloteaux B*, Heuze F*, Klitgord N*, Tam S, Yu H, Venkatesan K, Mou D, Swearingen V, Yildirim MA, Yan H, Dricot A, Szeto D, Lin C, Hao T, Fan C, Milstein S, Dupuy D, Brasseur R, Hill DE, Cusick ME, Vidal M. Edgetic perturbation models of human inherited disorders. Mol Syst Biol 5:321. (2009) *Equal contributors
 [Highlighted in Mol Syst Biol 5:322 (2009)
; Nat Rev Genet 11:4-5 (2010)
; Nature 463:405 (2010)

Dreze M*, Charloteaux B*, Milstein S*, Vidalain PO*, Yildirim MA, Zhong Q, Svrzikapa N, Romero V, Laloux G, Brasseur R, Vandenhaute J, Boxem M, Cusick ME, Hill DE, Vidal M. ‘Edgetic’ perturbation of a C. elegans BCL2 ortholog.  Nat Methods 6:843-9. (2009) *Equal contributors
 [Highlighted in Nat Methods 6:797-8 (2009)


De Nicolo A, Parisini E*, Zhong Q*, Dalla Palma M, Stoeckert KA, Domchek SM, Nathanson KL, Caligo MA, Vidal M, Cusick ME, Garber JE. Multimodal assessment of protein functional deficiency supports pathogenicity of BRCA1. Cancer Res 69:7030 (2009) *Equal contributors

Zhou J*, Zhong Q*, Li G, Greenberg ML. Loss of cardiolipin leads to longevity defects that are alleviated by alterations in stress response signaling.J Biol Chem 284:18106 (2009) *Equal contributors

Li QR*, Carvunis AR*, Yu H*, Han JD*, Zhong Q, Simonis N, Tam S, Hao T, Klitgord NJ, Dupuy D, Mou D, Wapinski I, Regev A, Hill DE, Cusick ME, Vidal M. Revisiting the Saccharomyces cerevisiae predicted ORFeome. Genome Res 18:1294. (2008) *Equal contributors

Zhong Q*, Li G*, Gvozdenovic-Jeremic J, Greenberg ML. Up-regulation of the cell integrity pathway in Saccharomyces cerevisiae suppresses temperature sensitivity of the pgs1Δ mutant.  J Biol Chem 282:15946. (2007) *Equal contributors

Zhong Q, Greenberg ML. Deficiency in mitochondrial anionic lipids synthesis impairs cell wall biogenesis. Biochem Soc Trans 33:1158. Review. (2005)

Zhong Q*, Gvozdenovic-Jeremic J*, Webster P, Zhou J, Greenberg ML. Loss of function of KRE5 suppresses temperature sensitivity of mutants lacking mitochondrial anionic lipids.   Mol Biol Cell 16:665-75. (2005) *Equal contributors

Zhong Q* Gohil VM* Ma L* Greenberg ML. Absence of cardiolipin results in temperature sensitivity, respiratory defects, and mitochondrial DNA instability independent of pet56 .J Biol Chem 279:32294. (2004) *Equal contributors

Zhong Q, Greenberg ML. Regulation of phosphatidylglycerophosphate synthase by inositol in Saccharomyces cerevisiae is not at the level of PGS1 mRNA abundance.   J Biol Chem 278:33978. (2003)

Gu Z*, Gohil V*, Zhong Q*, Schlame M and Greenberg ML. The biosynthesis and remodeling of cardiolipin in LIPIDS: Glycerolipid Metabolizing Enzymes. (Haldar, D. and Das, S.K., ed.) pp 67-84. Review. (2002) *Equal contributors

Cui JP, Zhong Q, Li WZ, Yan J, Shen DL. Factors affecting population biology of Wolbachia in the small brown planthoppers, Laodelphax striatellus (Homoptera: Delphacidae).  J Fudan Univ: Nat Sci 37:542 (1998)

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