S. Dean Rider, Jr., Ph.D.

Pharmacology & Toxicology-SOM
Research Assistant Professor
Biological Sciences Bldg II 163, 3640 Colonel Glenn Hwy, Dayton, OH 45435-0001

Education History

Ph.D.: 2000 Purdue University
Postdoctoral: Purdue University
Postdoctoral: Texas A&M University

Research Statement

My research has focused on genome instability and sources of mutation in mammalian systems. Research includes understanding environmental causes of mutagenesis as well as simple sequence repeats, the proteins involved in regulating their stability, and their relationship to genome rearrangements, human performance and human disease.


  1. Cvammen, W., Rider, S.D., Travers, J.B., and Kemp, M.G., 2023. Effects of age and sex on the expression of core circadian clock genes in human skin epidermis. Journal of Investigative Dermatology. https://doi.org/10.1016/j.jid.2023.10.020
  2. S. Dean Rider, Jr., Rujuta Yashodhan Gadgil, David C. Hitch, French J. Damewood, IV, Nathen Zavada, Matilyn Shanahan, Venicia Alhawach, Resha Shrestha, Kazuo
    Shin-ya, Michael Leffak. 2022. Stable G-quadruplex DNA structures promote replication-dependent genome instability. Journal of Biological Chemistry. Open Access DOI:https://doi.org/10.1016/j.jbc.2022.101947
  3. Gadgil RY, Rider SD Jr, Lewis T, Barthelemy J, Leffak M. 2020. Analysis of Trinucleotide Repeat Stability by Integration at a Chromosomal Ectopic Site. Methods Mol Biol. 2056:121-136. doi: 10.1007/978-1-4939-9784-8_8. PubMed PMID: 31586345.
  4. Rider, Jr., S.D., D. G. Srinivasan, and R.S. Hilgarth. 2010. Chromatin-Remodelling Proteins of the Pea Aphid, Acyrthosiphon pisum (Harris). Insect Molecular Biology, S2: 201-214.
  5. International Aphid Genomics Consortium (includes S. D. Rider, Jr.). 2010. Genome Sequence of the Pea Aphid Acyrthosiphon pisum. PLoS Biology. 8: e1000313.
  6. Ramsey, J.S., Rider, D.S., Walsh, T.K., De Vos, M., Gordon, K.H.J., Ponnala, S.L., Macmil, S., Roe, B.A., and Jander, G. 2010. Comparative analysis of detoxification enzymes in Acrythosiphon pisum and Myzus persicae. Insect Molecular Biology S2: 155-164.
  7. Rider, Jr., S. D., and G. Zhu. 2010. Cryptosporidium: Genomic and Biochemical Features. Exp. Parasitol. 124: 2-9.
  8. Rider, Jr., S. D., and G. Zhu. 2009. An Apicomplexan Ankyrin Repeat Histone Deacetylase with Relatives in Photosynthetic Eukaryotes. Int. J. Parasitol, 39: 747-754. [COVER ARTICLE]
  9. Muir, W. M., Rosa, G. J. M., Pittendrigh, B. R., Xu, S., Rider, S. D., Fountain, M., and Ogas, J. 2009. A mixture model approach for the analysis of small exploratory microarray experiments. Computational Statistics and Data Analysis, 53: 1566-1576.
  10. Rider, Jr. S. D., and G. Zhu. 2008. Differential Expression of the two distinct Replication Protein A subunits from Cryptosporidium parvum. J. Cell. Biochem 104: 2207-2216.
  11. Zhang, H., Rider, Jr., S. D., Henderson, J. T., Fountain, M., Chuang, K., Kandachar, V., Simons, A., Jerome, R. J., Edenberg, H. J., Romero-Severson, J., Muir, W. M., and Ogas, J. P. 2008. The CHD3 remodeler PICKLE promotes trimethylation of histone H3 lysine 27. J. Biol. Chem. 283: 22637-22648.
  12. Rider, Jr. S. D., and G. Zhu. "Apicomplexans - Cryptosporidium spp." In Emerging Protozoan Pathogens. Ed. N. A. Khan. Oxford: Taylor & Francis, 2007. 193-225.
  13. Muir, W. M., Romero-Severson, J., Rider, Jr., S. D., Simons, A., Ogas, J., 2006. Application of one-sided t-tests and a generalized experiment wise error rate to high-density oligonucleotide microarray experiments: An example using Arabidopsis. J. Data Sci. 4: 323-341.
  14. Li, H.-C., Chuang, K., Henderson, J. T., Rider, Jr., S. D., Bai, Y., Zhang, H., Fountain, M., Gerber, J., and Ogas, J. 2005. PICKLE acts during germination to repress expression of embryonic traits. Plant J. 44(6):1010-1022.
  15. Rider, Jr., S. D., Cai, X-M., Sullivan, Jr., W. J., Smith, A. T., Radke, J., White, M. and Zhu, G., 2005. The Protozoan Parasite Cryptosporidium parvum Possesses Two Functionally and Evolutionarily Divergent Replication Protein A Large Subunits. J. Biol. Chem. 280(36):31460-31469.
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