Mike Kemp, Ph.D.

Department:
Pharmacology & Toxicology-SOM
Title:
Assistant Professor, Pharmacology & Toxicology
Address:
Biological Sciences Bldg II 142, 3640 Colonel Glenn Hwy, Dayton, OH 45435-0001

Pictures of my laboratory along with a summary of the current projects in my laboratory can be found in the PDF files at the bottom of this page.

For a short video overview of my research and teaching, click here.

Curriculum Vitae

Kemp_CV_072721.pdf 255.29 KB

News

  • Sept 9, 2021: Nadeen's paper on the effect of circadian clock modulating drugs on cisplatin responses is published in Scientific Reports
  • July 23, 2021: Alex wins a poster award at the ASBMB virtual meeting "Extracellular vesicle studies: from benchtop to therapeutics"!
  • June 6, 2021: A review article on the circadian clock in the skin written by MD/MS student Janet Lubov, BMS PhD student Billy Cvammen, and Dr. Kemp has been accepted for publication!
  • May 2021: All lab members are vaccinated against SARS-CoV-2!
  • May 8, 2021: Alex gave an excellent plenary talk at the virtual SID meeting.
  • April 30, 2021: Billy passes his preliminary exam!
  • April 27, 2021: Nadeen defends her master's thesis!
  • April 16, 2021: Vivek defends his master's thesis!
  • April 15, 2021: Meghana defends her master's thesis!
  • March 18, 2021: Our manuscript showing PCNA ubiquitination in human skin has been accepted for publication in the Journal of Biological Chemistry!
  • February 11, 2021: Alex's abstract was selected for a plenary talk at the Society for Investigative Dermatology (Virtual) Meeting in May!
  • February 1, 2021: Dr. Saman Khan joins the Kemp lab as a Postdoctoral Researcher!
  • August 2021: Dr. Kemp gives a talk at the Environmental Mutagenesis and Genomics Society virtual meeting
  • July 1, 2020: Dr. Kemp's grant proposal "Circadian Modulating Drugs in Cancer Prevention and Treatment was selected for funding by Ohio Cancer Research!
  • May 13-16, 2020: Dr. Kemp gives a talk at the 2020 Society for Investigative Dermatology Meeting Virtual Conference.

 

Research Statement

My research interests are in the area of the cellular DNA damage response, with a specific focus on DNA repair, DNA replication, and DNA damage kinase signaling in UV-irradiated human skin. In addition to finding new ways to prevent skin cancer, we are also interested in improving the effectiveness of cancer chemotherapy regimens involving DNA damaging agents through modification of DNA damage responses and the circadian clock.

My laboratory is currently funded by grants from the National Institute of General Medical Sciences, the Veteran's Administration, and Ohio Cancer Research Associates.

A PDF summary of the current projects in my laboratory can be found at the bottom of this page.

 

Students Advised

My laboratory trains postdoctoral researchers as well as graduate students in the Pharmacology and Toxicology Master's Degree Program and the Biomedical Sciences Ph.D. Program

Current Trainees:

  1. Dr. Saman Khan, PhD (Postdoctoral; 2021-present)
  2. Billy Cvammen (Biomedical Sciences PhD; 2020-present)
  3. Dr. Alex Carpenter, PhD (Postdoctoral; 2020-present)

Previous Trainees:

  1. Nadeen Anabtawi, PharmD (Pharm/Tox MS; 2019-2021)
  2. Vivek Gogusetti (Pharm/Tox MS; 2019-2021)
  3. Meghana Ginugu (Pharm/Tox MS; 2019-2021)
  4. Amber Castellanos (Anatomy MS; 2019-2020)
  5. Mariyyah Madkhali (Pharm/Tox MS: 2018-2020)
  6. Abdulrahman Alkawar (Pharm/Tox MS: 2018-2020)
  7. Rebekah Hutcherson (Biochem/Mol Bio BS Honors: 2018-2019)
  8. Kavya Shaj, PharmD (Pharm/Tox MS: 2017-2019)

Students wishing to carry out thesis research in my laboratory are required to become vaccinated against SARS-CoV-2 and are strongly encouraged to take PTX7002 (Journal Club: Genome Stability and Human Disease) and PTX8020 (Pharmacology & Toxicology of DNA Damaging Agents; Spring semester), which provide background context and knowledge related to the types of research being performed in my laboratory. Thus, students taking these courses will be better acquainted with my research program and may be given priority for admittance as a graduate student in my lab. For more information about suggestions and expectations for students working in my lab, see the "Expections and suggestions for graduate students" file at the bottom of the screen. Due to limited space in the lab for current and expected personnel and ongoing COVID concerns, I must limit the number of students that I can admit into my lab. Finally, because of changes in WSU policy on tuition waivers, it is unlikely that I will be able to provide master's levels students with graduate research assistantships that involve tuition waivers (however, other compensation may be possible).

 

Service

  • Chair, Awards & Honors Committee, Environmental Mutagenesis and Genomics Society
  • Education Commitee, WSU Dept of Pharmacology & Toxicology

 

Publications

(2017-present)

  1. Anabtawi N, Cvammen W, and Kemp MG. (2021). Pharmacological inhibition of cryptochrome and REV-ERB promotes DNA repair and cell cycle arrest in cisplatin-treated human cells. Scientific Reports. 11: 17997.
  2. Carpenter MA and Kemp MG. (2021-in press). Topical treatment of human skin and cultured keratinocytes with high-dose spironolactone reduces XPB expression and induces toxicity. JID Innovations. (in press).
  3. Sarkar S, Porter KI, Dakup PP, Gajula RP, Koritala BSC, Hylton R, Kemp MG, Wakamatsu K, and Gaddameedhi S. (2021). Circadian clock protein BMAL1 regulates melanogenesis through MITF in melanoma cells. Pigment Cell Melanoma Res. 34(5): 955-965.
  4. Spandau DF, Chen R, Wargo JJ, Rohan CA, Southern D, Zhang A, Loesch M, Weyerbacher J, Thopady SS, Lewis DA, Kuhar M, Tsai KY, Castellanos AJ, Kemp MG, Markey M, Cates E, Williams AR, Knisely C, Bashir S, Gabbard R, Hoopes R, and Travers JB. (2021). Randomized controlled trial of fractionated laser resurfacing to aged skin as prophylaxis against actinic neoplasia. J Clin Invest. 24: 149072.
  5. Lubov JE, Cvammen W, and Kemp MG (2021). The Impact of the Circadian Clock on Skin Physiology and Cancer Development. Int J Mol Sci. 22(11): 6112.
  6. Liu L, Awayemi AA, Fahy KE, Thapa P, Borchers C, Wu BY, McGlone CL, Schmeusser B, Sattouf Z, Rohan CA, Williams AR, Cates EE, Knisely C, Kelly LE, Bihl J, Cool DR, Sahu RP, Wang J, Chen Y, Rapp CM, Kemp MG, Johnson RM, and Travers JB. (2021). Keratinocyte-derived microvesicle particles mediate ultraviolet B radiation induced system immunosuppression. J Clinical Investigation. 131(10): e144963.
  7. Hutcherson RJ, Gabbard RD, Castellanos AJ, Travers JB, and Kemp MG. (2021). Age and insulin-like growth factor-1 impact PCNA mono-ubiquitination in UVB-irradiated human skin. J Biol Chem. 100570. YouTube summary: click here.
  8. Ume AC, Pugh JM, Kemp MG, Williams CR. (2020). Calcineurin inhibitor (CNI)-associated skin cancers: New insights on exploring mechanisms by which CNIs downregulate DNA repair machinery. Photoderm Photoimmunol Photomed. 36(6): 433-440.
  9. Alkawar AMM, Castellanos AJ, Carpenter MA, Hutcherson RJ, Madkhali MAO, Johnson RM, Bottomley M, and Kemp MG. (2020). Insulin-like Growth Factor-1 Impacts p53 Target Gene Induction in UVB-irradiated Keratinocytes and Human Skin. Photochemistry & Photobiology. 96(6): 1332-1341. YouTube summary: click here.
  10. Gabbard RD, Hoopes RR, and Kemp MG. (2020). Spironolactone and XPB: An Old Drug with a New Molecular Target. Biomolecules. 10(5): 756.
  11. Choi J-H, Han S, and Kemp MG. (2020). Detection of the small oligonucleotide products of nucleotide excision repair in UVB-irradiated human skin. DNA Repair. 86: 102766. YouTube summary: click here.
  12. Travers JB, Kemp MG, Weir NM, Cates E, Alkawar AM, Majahan AS, Spandau DF. (2020). Wounding with a microneedling device corrects the inappropriate ultraviolet B radiation response in geriatric skin. Arch Dermatol Res. 312(1): 1-4.
  13. Shaj K, Hutcherson RJ, Kemp MG. (2020). ATR kinase activity limits mutagenesis and promotes the clonogenic survival of quiescent human keratinocytes exposed to UVB radiation. Photochemistry & Photobiology. 96(1): 105-112. YouTube summary: click here.
  14. Hutcherson RJ and Kemp MG. (2019). ATR kinase inhibition sensitizes quiescent human cells to the lethal effects of cisplatin but increases mutagenesis. Mutation Research. 816-818: 111678. YouTube summary: click here.
  15. Kemp MG. (2019). Damage removal and gap filling in nucleotide excision repair. The Enzymes: DNA Repair, 45: 59-97.
  16. Kemp MG, Krishnamurthy S, Kent MN, Schumacher DL, Sharma P, Excoffon KJDA, Travers JB. (2019). Spironolactone depletes the XPB protein and inhibits DNA damage responses in UVB-irradiated human skin. J Invest Dermatology.139(2): 448-454. YouTube summary: click here.
  17. Khan AQ, Travers JB, and Kemp MG. (2018). Roles of UVA Radiation and DNA Damage Responses in Melanoma Pathogenesis. Environmental and Molecular Mutagenesis, 59(5): 438-60.
  18. Poudel S, Yao J, Kemp MG, Leffak M. (2018). Interaction between DUE-B and Treslin is required to load Cdc45 on chromatin in human cells. J Biol Chem. 293(37): 14497-14506.
  19. Dakup PP, Porter KI, Little AA, Gajula RP, Zhang H, Skorynakov E, Kemp MG, Van Dongen HPA, and Gaddameedhi S. (2018). The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models. Oncotarget. 9(18): 14524-14538.
  20. Baek S, Han S, Kang D, Kemp MG*, Choi JH. (2018). Simultaneous detection of nucleotide excision repair events and apoptosis-induced DNA fragmentation in genotoxin-treated cells. Scientific Reports. 8(2265): 1-11. (*co-corresponding author) YouTube summary: click here.
  21. Kemp MG, Spandau DF, and Travers JB. (2017). Impact of Age and Insulin-like Growth Factor-1 on DNA Damage Responses in UV-irradiated Human Skin. Molecules. 22(3).
  22. Kemp MG. (2017). DNA damage-induced ATR kinase activation in non-replicating cells is regulated by the XPB subunit of transcription factor II-H (TFIIH). J Biol Chem. 292(30): 12424-12435.
  23. Kemp MG, Spandau DF, Simman R, and Travers JB. (2017). Insulin-like Growth Factor-1 Receptor Signaling is Required for Optimal ATR-CHK1 Kinase Signaling in Ultraviolet B (UVB)-irradiated Human Keratinocytes. J Biol Chem. 292(4): 1231-9. YouTube summary: click here.
  24. Kemp MG and Hu J. (2017). Post-Excision Events in Human Nucleotide Excision Repair. Photochemistry & Photobiology. 93(1): 178-91.
  25. Song J, Kemp MG and Choi J-H. (2017). Detection of the Excised, Damage-containing Oligonucleotide Products of Nucleotide Excision Repair in Human Cells. Photochemistry & Photobiology. 93(1): 192-8.

Check out my full list of publications on PubMed.

 

Education History

EDUCATION

1999 B.S. in Biological Sciences,  Wright State University, Dayton, Ohio

2006 Ph.D. in Biomedical Sciences, Wright State University, Dayton, Ohio

 

POST-DOCTORAL TRAINING

2006-2011 DNA Repair and DNA Damage Signaling, University of North Carolina Department of Biochemistry & Biophysics, Chapel Hill, NC

2016-2017 Skin Biology and Aging, Wright State University Department of Pharmacology & Toxicology, Dayton, Ohio

 

Professional Affiliations/Memberships

  • American Society for Biochemistry and Molecular Biology (ASBMB), 2015-present
  • Environmental Mutagenesis and Genomics Society (EMGS), 2016-present
  • American Society for Photobiology (ASP), 2016-present
  • Society for Investigative Dermatology (SID), 2017-present

 

Awards/Recognition

  • June 2021: VA Clinical Merit Award CX002241 - "Mapping DNA Repair and Error-Prone DNA Synthesis in Geriatric Skin"
  • July 2020: Ohio Cancer Research Grant #5020 - "Circadian Clock Modulating Drugs in Cancer Prevention and Treatment"
  • May 2019: Newly Independent Investigators Engagement Program, Environmental Mutagenesis and Genomics Society
  • Feb 2019: NIGMS R01 Award GM130583 - "DNA Damage Kinase Signaling in Non-replicating Human Cells and Tissues"
  • Mar 2018: Travel Award, Society for Investigative Dermatology
  • Sept 2016: Emerging Scientist Travel Award, Environmental Mutagenesis and Genomic Society

 

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